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dc.contributor.authorZatu, Mandlenkosi C.
dc.contributor.authorVan Rooyen, Johannes M.
dc.contributor.authorLoots, Du Toit
dc.contributor.authorWentzel-Viljoen, Edelweiss
dc.contributor.authorGreeff, Minrie
dc.contributor.authorSchutte, Aletta E.
dc.identifier.citationZatu, M.C. et al. 2014. Self-reported alcohol intake is a better estimate of 5-year change in blood pressure than biochemical markers in low resource settings: the PURE study. Journal of hypertension, 32(4):749-755. []en_US
dc.identifier.issn1473-5598 (Online)
dc.description.abstractBackground: Despite criticism of self-reported alcohol intake, it is a valuable tool to screen for alcohol abuse as a risk factor for cardiovascular disease. We aimed to compare various self-reported estimates of alcohol use with γ-glutamyltransferase (GGT) and percentage carbohydrate deficient transferrin (%CDT) considering their relationship with blood pressure changes (%BP) over a 5-year period in black South Africans. Method: We recruited 1994 participants and collected 5-year followed up data (N = 1246). Participants completed questionnaires on alcohol intake indicating their former and current alcohol use (‘yes’ response and ‘no’ if alcohol was never used). We assessed alcohol intake (in g) using a quantified food frequency questionnaire. We collected blood samples and measured GGT and %CDT. Brachial BP (bBP) was measured at baseline and follow-up and central BP (cBP) at follow-up only. Results: Self-reported alcohol intake was significantly associated with the 5-year change in bBP before and after adjusting for confounders (%bSBP: R$^2$ = 0.263, β = 0.06, P = 0.023; %bDBP: R$^2$ = 0.326, β = 0.08 P = 0.005), as well as cSBP (R$^2$ = 0.286, β = 0.09, P = 0.010) and central pulse pressure (R2 = 0.254, β = 0.06, P = 0.020). GGT and %CDT correlated well with self-reported alcohol intake (r = 0.44; P = 0.001; r = 0.34 P = 0.001), but did not associate significantly with %bBP or cBP at follow-up. Conclusion: Self-reported alcohol use was strongly associated with a 5-year increase in BP in Africans with a low socio-economic status. This was not found for biochemical measures, GGT and %CDT. Self-reported alcohol intake could be an important measure to implement in primary healthcare settings in middle to low income countries, where honest reporting is expected.en_US
dc.publisherWolters Kluweren_US
dc.subjectBlood pressureen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectLow socio-economic statusen_US
dc.subjectPercentage carbohydrate deficient transferrinen_US
dc.subjectSelf-reported alcohol intakeen_US
dc.titleSelf-reported alcohol intake is a better estimate of 5-year change in blood pressure than biochemical markers in low resource settings: the PURE studyen_US
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus
dc.contributor.researchID10799508 - Loots, Du Toit
dc.contributor.researchID10998497 - Wentzel-Viljoen, Edelweiss
dc.contributor.researchID10187308 - Greeff, Minrie
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID13059165 - Zatu, Mandlenkosi Caswell

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