dc.contributor.author | Harvey, Brian H. | |
dc.contributor.author | Joubert, Charise | |
dc.contributor.author | Du Preez, Jan L. | |
dc.contributor.author | Berk, Michael | |
dc.date.accessioned | 2009-08-31T13:51:23Z | |
dc.date.available | 2009-08-31T13:51:23Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Harvey, B.H. et al. 2008. Effect of chronic N-acetyl cystine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum. Neurochemical research, 33(3):508-517. [https://doi.org/10.1007/s11064-007-9466-y] | en |
dc.identifier.issn | 0364-3190 | |
dc.identifier.issn | 1573-6903 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/2192 | |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs11064-007-9466-y | |
dc.identifier.uri | https://doi.org/10.1007/s11064-007-9466-y | |
dc.description.abstract | Antioxidants have possible therapeutic value in neurodegenerative disorders, although they may have pro-oxidant effects under certain conditions. Glutathione (GSH) is a key free radical scavenger. N-acetylcysteine (NAC) bolsters GSH and intracellular cysteine and also has effective free radical scavenger properties. The effects of chronic NAC administration (50 mg/kg/day, 500 mg/kg/day, 1500 mg/kg/day × 21 days) on cellular markers of oxidative status was studied in striatum of healthy male Sprague-Dawley rats as well as in animals with apparent striatal oxidative stress following chronic haloperidol treatment (1.5 mg/kg/day × 3 weeks). In non-haloperidol treated animals, NAC 50 and 500 mg/kg did not affect oxidative status, although NAC 1,500 mg/kg significantly increased striatal superoxide levels, decreased lipid peroxidation and increased consumption of reduced glutathione (GSH). Haloperidol alone evoked a significant increase in superoxide and lipid peroxidation. All NAC doses blocked haloperidol induced increases in superoxide levels, while NAC 500 mg/kg and 1,500 mg/kg prevented haloperidol-associated lipid peroxidation levels and also increased the GSSG/GSH ratio. NAC may protect against conditions of striatal oxidative stress, although possible pro-oxidative actions at high doses in otherwise healthy individuals, e.g. to offset worsening of neurodegenerative illness, should be viewed with caution | |
dc.language.iso | en | en |
dc.publisher | Springer | |
dc.subject | N-acetylcysteine, Striatum, Oxidative stress | |
dc.subject | Haloperidol | |
dc.subject | Neurodegenerative disorder | |
dc.title | Effect of chronic N-acetyl cystine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum | en |
dc.type | Article | en |
dc.contributor.researchID | 11083417 - Harvey, Brian Herbert | |
dc.contributor.researchID | 10060510 - Du Preez, Jan Lourens | |