dc.contributor.author | Zatu, Mandlenkosi C. | |
dc.contributor.author | Van Rooyen, Johannes M. | |
dc.contributor.author | Kruger, Annamarie | |
dc.contributor.author | Schutte, Aletta E. | |
dc.date.accessioned | 2017-05-15T07:21:37Z | |
dc.date.available | 2017-05-15T07:21:37Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Zatu, M.C. et al. 2016. Alcohol intake, hypertension development and mortality in black South Africans. European journal of preventive cardiology, 23(3):308-315. [http://dx.doi.org/10.1177/2047487314563447] | |
dc.identifier.issn | 2047-4873 | |
dc.identifier.issn | 2047-4881 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/23059 | |
dc.identifier.uri | http://dx.doi.org/10.1177/2047487314563447 | |
dc.description.abstract | Background: Excessive alcohol intake is a risk factor for cardiovascular disease (CVD) and predicts cardiovascular and
all-cause mortality. We determined which alcohol marker (self-reported alcohol intake, gamma-glutamyltransferase
(GGT) or percentage carbohydrate deficient transferrin (%CDT)) relates best with mortality and predicts hypertension
development over five years in black South Africans.
Design: This was a longitudinal study as part of the PURE (Prospective Urban and Rural Epidemiology) study in the
North West Province, South Africa.
Method: We included 2010 participants and followed 1471 participants. Over five years, 230 deaths occurred, of which
66 were cardiovascular-related. At enrolment, participants completed questionnaires on alcohol intake (yes, for former
and current use; no, for alcohol never used).We measured blood pressure, collected blood samples and measured GGT
and %CDT.
Results: When comparing hazard ratios (HRs) of self-report, GGT and %CDT, we found that only GGT predicted
cardiovascular (HR¼2.76 (1.49–5.12)) and all-cause mortality (HR¼2.47 (1.75–3.47)) and hypertension development
((HR¼1.31 (1.06–1.62)). Participants self-reporting yes for alcohol intake had a 30% increased risk of developing
hypertension (HR¼1.30 (1.07–1.60)) but not an increased risk for mortality. When adding both GGT and self-report
in the prediction model for hypertension, only self-reporting of alcohol was significant (HR¼1.24 (1.01–1.53)). The
alcohol marker, %CDT, did not show any significant association with mortality or hypertension development.
Conclusion: GGT independently predicted cardiovascular and all-cause mortality, as well as hypertension development
in black South Africans. Despite non-specificity to excessive alcohol consumption, GGT may be a useful general marker
for hypertension development and mortality, also due to its significant association with self-reported alcohol intake | |
dc.language.iso | en | |
dc.publisher | Sage Publishing | |
dc.subject | Gamma-glutamyltransferase | |
dc.subject | Percentage carbohydrate deficient transferrin | |
dc.subject | Self-reported alcohol intake | |
dc.subject | Hypertension | |
dc.subject | Morbidity | |
dc.subject | Sub-Saharan Africa | |
dc.subject | Cardiovascular disease | |
dc.title | Alcohol intake, hypertension development and mortality in black South Africans | |
dc.type | Article | |
dc.contributor.researchID | 10062416 - Kruger, Annamarie | |
dc.contributor.researchID | 10922180 - Schutte, Aletta Elisabeth | |
dc.contributor.researchID | 10059539 - Van Rooyen, Johannes Marthinus | |
dc.contributor.researchID | 13059165 - Zatu, Mandlenkosi Caswell | |