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dc.contributor.authorScheepers, Jacobus De Wet
dc.contributor.authorMalan, Leoné
dc.contributor.authorDe Kock, Andrea
dc.contributor.authorMalan, Nicolaas Theodor
dc.contributor.authorCockeran, Marike
dc.contributor.authorVon Känel, Roland
dc.identifier.citationScheepers, J.D.W. et al. 2016. Hypercoagulation and hyperkinetic blood pressure indicative of physiological loss-of-control despite behavioural control in Africans: the SABPA study. Blood pressure, 25(4):219-227. []
dc.identifier.issn1651-1999 (Online)
dc.description.abstractObjectives: A dissociation between behavioural (in-control) and physiological parameters (indicating loss-of-control) is associated with cardiovascular risk in defensive coping (DefS) Africans. We evaluated relationships between DefS, sub-clinical atherosclerosis, low-grade inflammation and hypercoagulation in a bi-ethnic sex cohort. Methods: Black (Africans) and white Africans (Caucasians) (n = 375; aged 44.6 ± 9.7 years) were included. Ambulatory BP, vascular structure (left carotid cross-sectional wall area (L-CSWA) and plaque counts), and markers of coagulation and inflammation were quantified. Ethnicity/coping style interaction was revealed only in DefS participants. Results: A hypertensive state, less plaque, low-grade inflammation, and hypercoagulation were more prevalent in DefS Africans (27–84%) than DefS Caucasians (18–41%). Regression analyses demonstrated associations between L-CSWA and 24 hour systolic BP (R2 = 0.38; β = 0.78; p < 0.05) in DefS African men but not in DefS African women or Caucasians. No associations between L-CSWA and coagulation markers were evident. Conclusion: Novel findings revealed hypercoagulation, low-grade inflammation and hyperkinetic BP (physiological loss-of-control responses) in DefS African men. Coupled to a self-reported in-control DefS behavioural profile, this reflects dissociation between behaviour and physiology. It may explain changes in vascular structure, increasing cerebrovascular disease risk in a state of hyper-vigilant coping
dc.publisherTaylor & Francis
dc.subjectStructural vascular disease
dc.subjectVascular remodelling
dc.titleHypercoagulation and hyperkinetic blood pressure indicative of physiological loss-of-control despite behavioural control in Africans: the SABPA study
dc.contributor.researchID21102007 - Cockeran, Marike
dc.contributor.researchID20273371 - De Kock, Andrea
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID20765274 - Scheepers, Jacobus De Wet
dc.contributor.researchID25499777 - Von Känel, Roland

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