dc.contributor.author | Kruger, R. | |
dc.contributor.author | Schutte, A.E. | |
dc.contributor.author | Mels, C.M.C. | |
dc.contributor.author | Smith, W. | |
dc.contributor.author | Van Rooyen, J.M. | |
dc.contributor.author | Kruger, I.M. | |
dc.contributor.author | Fourie, C.M.T. | |
dc.date.accessioned | 2017-08-22T11:27:16Z | |
dc.date.available | 2017-08-22T11:27:16Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Kruger, R. et al. 2017. Cardiac troponin T as early marker of subclinical cardiovascular deterioration in black hypertensive women. Heart, lung and circulation, 26(8):825-832. [http://dx.doi.org/10.1016/j.hlc.2016.11.010] | en_US |
dc.identifier.issn | 1443-9506 | |
dc.identifier.issn | 1444-2892 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/25411 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.hlc.2016.11.010 | |
dc.description.abstract | Background
Hypertensive heart disease is a rising concern, especially among black South African women. As high sensitivity cardiac troponin T (cTnT) is a marker of cardiomyocyte damage, we determined the potential link of (i) systemic endothelial dysfunction (reflected by urinary albumin-to-creatinine ratio), (ii) large artery stiffness, (iii) cardiac volume load (estimated by the N-terminal prohormone B-type natriuretic peptide (Nt-proBNP)), and (iv) ECG left ventricular hypertrophy in post-menopausal black women.
Methods
In 121 (50 normotensive and 71 hypertensive) black women (mean age: 60.6 years), basic cardiovascular assessments including blood pressure and ECG were performed, along with plasma and urinary biomarkers including cTnT.
Results
The cTnT levels (p=0.049) along with Nt-proBNP (p=0.003), pulse pressure (p<0.0001) and the Cornell product (p=0.030) were higher in hypertensive than normotensive women. Only in hypertensive women, was cTnT independently associated with urinary albumin-to-creatinine ratio (β=0.25; p=0.019), pulse pressure (β=0.31; p=0.019), Nt-proBNP (β=0.47; p<0.0001) and Cornell product (β=0.31; p=0.018). An independent association between albumin-to-creatinine ratio and cTnT was also evident in normotensive women (β=0.34; p=0.037).
Conclusion
We found cTnT to be a useful marker in an elderly black population relating to several measures of cardiovascular deterioration – from subclinical endothelial dysfunction to left ventricular hypertrophy | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Troponin T | en_US |
dc.subject | Endothelial dysfunction | en_US |
dc.subject | Arterial stiffness | en_US |
dc.subject | Left ventricular hypertrophy | en_US |
dc.subject | Hypertension | en_US |
dc.title | Cardiac troponin T as early marker of subclinical cardiovascular deterioration in black hypertensive women | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 20035632 - Kruger, Ruan | |
dc.contributor.researchID | 10922180 - Schutte, Aletta Elisabeth | |
dc.contributor.researchID | 12076341 - Mels, Catharina Martha Cornelia | |
dc.contributor.researchID | 22945717 - Smith, Wayne | |
dc.contributor.researchID | 10059539 - Van Rooyen, Johannes Marthinus | |
dc.contributor.researchID | 12079642 - Kruger, Iolanthé Marike | |
dc.contributor.researchID | 10062491 - Fourie, Catharina Maria Theresia | |