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dc.contributor.authorEsterhuizen, Karien
dc.contributor.authorVan der Westhuizen, Francois H.
dc.contributor.authorLouw, Roan
dc.date.accessioned2017-08-22T13:27:34Z
dc.date.available2017-08-22T13:27:34Z
dc.date.issued2017
dc.identifier.citationEsterhuizen, K. et al. 2017. Metabolomics of mitochondrial disease. Mitochondrion, 35:97-110. [https://doi.org/10.1016/j.mito.2017.05.012]en_US
dc.identifier.issn1567-7249
dc.identifier.issn1872-8278 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/25418
dc.identifier.urihttps://doi.org/10.1016/j.mito.2017.05.012
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1567724916301453
dc.description.abstractMitochondrial disease (MD) diagnostics and disease progression investigations have traditionally relied very little on metabolic data, due to a lack of biomarker sensitivity and specificity. The recent drive to find novel, low intervention biomarkers and new therapeutic approaches have revived an interest in what metabolic data can offer, as presented in this timely review. We review how metabolomics has been applied to MD and provide an extensive overview of the reported metabolic perturbations and common mechanistic features that may provide a basis for future research. We conclude by highlighting the substantial potential of metabolomics for future diagnostics and mitochondrial medicineen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectMetabolomicsen_US
dc.subjectMitochondrial diseaseen_US
dc.subjectOXPHOSen_US
dc.subjectRespiratory chain deficiencyen_US
dc.subjectMetabolismen_US
dc.titleMetabolomics of mitochondrial diseaseen_US
dc.typeArticleen_US
dc.contributor.researchID10213503 - Van der Westhuizen, Francois Hendrikus
dc.contributor.researchID10986707 - Louw, Roan


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