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dc.contributor.authorHarmse, Rozanne
dc.contributor.authorWong, Ho Ning
dc.contributor.authorSmit, Frans J.
dc.contributor.authorN'Da, David D.
dc.contributor.authorHaynes, Richard K.
dc.date.accessioned2018-01-16T13:27:42Z
dc.date.available2018-01-16T13:27:42Z
dc.date.issued2017
dc.identifier.citationHarmse, R. et al. 2017. Activities of 11-azaartemisinin and N-sulfonyl derivatives against Neospora caninum and comparative cytotoxicities. ChemMedChem, 12(24):2094-2098. [https://doi.org/10.1002/cmdc.201700600]en_US
dc.identifier.issn1860-7179
dc.identifier.issn1860-7187 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/26110
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201700600
dc.identifier.urihttps://doi.org/10.1002/cmdc.201700600
dc.description.abstractNeosporosis caused by the apicomplexan parasite Neospora caninum is an economically important disease that induces abortion in dairy and beef cattle. There are no vaccines or drugs available on the market for control or treatment of the disease in bovines. The peroxide artemisinin and its derivatives used clinically for treatment of malaria are active against N. caninum and other apicomplexan parasites. We have now evaluated the activities of the readily accessible and chemically robust 11-azaartemisinin 5 and selected N-sulfonyl derivatives prepared as described in the accompanying paper against N. caninum tachyzoites grown in infected human foreskin fibroblasts. Azaartemisinin elicited an IC50 value of 150 nm, and the 2′,5′-dichloro-3′-thienylsulfonyl-11-azaartemisinin 17 was found to be the most active, with an IC50 value of 40 nm. Comparison with normal human fetal lung fibroblasts HFLF WI-38 revealed relatively benign cytotoxicity. The compounds were also screened in vitro against TK-10 (renal), UACC-62 (melanoma) and MCF-7 (breast) cancer cell lines; overall, in line with activities against HFLF cells, most compounds in the series were found to be inactiveen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectAntitumor
dc.subjectApicomplexan
dc.subjectArtemisinin
dc.subjectAzaartemisinin
dc.subjectNeospora caninum
dc.titleActivities of 11-azaartemisinin and N-sulfonyl derivatives against Neospora caninum and comparative cytotoxicitiesen_US
dc.typeArticleen_US
dc.contributor.researchID25904442 - Wong, Ho Ning
dc.contributor.researchID20547587 - Harmse, Rozanne
dc.contributor.researchID20926588 - Smit, Frans Johannes
dc.contributor.researchID20883072 - N'Da, David Dago
dc.contributor.researchID22966390 - Haynes, Richard Kingston


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