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dc.contributor.authorKirkedal, Christian
dc.contributor.authorWegener, Gregers
dc.contributor.authorMoreira, Fabricio
dc.contributor.authorJoca, Samia Regiane Lourenco
dc.contributor.authorLiebenberg, Nico
dc.date.accessioned2018-02-05T12:42:16Z
dc.date.available2018-02-05T12:42:16Z
dc.date.issued2017
dc.identifier.citationKirkedal, C. et al. 2017. A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats. Acta neuropsychiatrica, 29(6):324-329. [https://doi.org/10.1017/neu.2016.68]en_US
dc.identifier.issn0924-2708
dc.identifier.issn1601-5215 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/26242
dc.identifier.urihttps://doi.org/10.1017/neu.2016.68
dc.description.abstractObjective: The cannabinoid receptor 1 (CB1) and transient receptor potential cation channel subfamily V member 1 (TRPV1) are proposed to mediate opposite behavioural responses. Their common denominator is the endocannabinoid ligand anandamide (AEA), which is believed to mediate antidepressant-like effect via CB1-R stimulation and depressive-like effect via TRPV1 activation. This is supposed to explain the bell-shaped dose-response curve for anandamide in preclinical models. Methods: We investigated this assumption by administering the dual inhibitor of AEA hydrolysis and TRPV1 activation N -arachidonoyl- serotonin (AA-5HT) into the medial prefrontal cortex of rats. AA-5HT was given in three different doses (0.125, 0.250, 0.500 nmol/0.4 μ l/side) and rat behaviour was assessed in the forced swim test. Results: Our results show signi fi cant antidepressant-like effect of AA-5HT (0.250 nmol) but no effects of low or high doses. The effect of 0.250 nmol AA-5HT was partially attenuated when coadministering the inverse CB1-agonist rimonabant (1.6 μ g). Conclusion: A 0.250 nmol of AA-5HT administration into the medial prefrontal cortex induced a signi fi cant antidepressant-like effect that was partially attenuated by locally blocking CB1-receptor
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.subjectCannabinoid receptor 1en_US
dc.subjectFatty acid amide hydrolaseen_US
dc.subjectForced swim testen_US
dc.subjectMedial prefrontal cortexen_US
dc.subjectTrans potential vanilloid receptor 1en_US
dc.titleA dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in ratsen_US
dc.typeArticleen_US
dc.contributor.researchID22353003 - Wegener, Gregers


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