Browsing by Advisor/Supervisor
Now showing items 1-13 of 13
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Dihydroartemisinin esters as prodrugs against resistant P. falciparum strains
(North-West University, 2011)Malaria is caused by the Plasmodium sp. parasite that infects the red blood cells. Of the four types of malaria, the most serious type is transmitted by Plasmodium falciparum species. It can be life threatening. The other ... -
Synthesis and anti-leishmanial activity of novel 2,3-disubstituted-4(3H)-quinazolinone derivatives
(North-West University (South Africa), 2020)Leishmaniasis is a disease resulting from the ingress of protozoan protists of the genus Leishmania (L.) into the mononuclear phagocytes of vertebrate hosts. These parasites are mainly transmitted by the haematophagous ... -
Synthesis and antileishmanial activity of novel benzothiadiazine-1,1-dioxide derivatives
(North-West University (South-Africa), 2021)Leishmaniasis claims thousands of lives of the human populace every year. Globally, it infects approximately 12-15 million people annually and estimations have indicated that approximately more than 350 million people are ... -
Synthesis and antimalarial activity of amine derivatives of artemisinin
(North-West University, 2012)Malaria has since antiquity been a leading cause of morbidity and mortality throughout the world having serious health, sociological and financial implications. Today, the parasite kills an approximate 655 000 people ... -
Synthesis and antimalarial activity screening of artemisinin-acridine hybrids
(2013)Malaria endemic areas not only pose a public health threat, but affects 3.3 billion people worldwide. In 2011, estimated malaria related deaths amounted to 660 000 out of 219 million reported cases, with 81% of these and ... -
Synthesis and biological evaluation of novel artemisone derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2015)Despite intensive international efforts to eradicate malaria, the disease, continues to inflict an enormous toll on human lives, especially in Africa. An estimated 198 million malaria cases and 584, 000 deaths were reported ... -
Synthesis and in vitro anti-protozoan activities of nitrofuran-based azine derivatives
(North-West University (South Africa), 2021)Neglected tropical diseases (NTDs) are a group of diverse infectious conditions that are closely connected to poverty and affects more than a billion people worldwide. Leishmaniasis is a vector-borne NTD that is caused by ... -
Synthesis and in vitro antileishmanial efficacy of novel O-substituted derivatives of Nifuroxazide
(North-West University (South-Africa), 2022)Leishmaniasis is a neglected tropical disease (NTD) caused by the Leishmania parasite and this devastating vector-borne disease affects millions of people worldwide. There are up to 1 million new infections reportedly ... -
Synthesis and in vitro antimalarial activity of a series of bistriazine compounds
(North-West University, 2012)Malaria persists to proliferate as an economic and social burden in the developing countries despite of a 17% decrease in the estimated number mortalities as reported by the World Health Organization in 2011. In the past ... -
Synthesis and in vitro antimalarial activity of novel chalcone derivatives
(2014)Malaria is endemic in 106 countries worldwide. This disease is caused by a parasite from the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most virulent, with over three billion ... -
Synthesis and in vitro antimalarial activity of series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
(North-West University, 2012)Every year an estimated 1 million people die of malaria, with the majority of these deaths reported in Africa. The disease caused by Plasmodium falciparum affects an approximate 250 million people annually and with the ... -
Synthesis and transdermal penetration of cytarabine and selected amide, ester and carbamate derivatives
(North-West University, 2009)Cancer is reported to be one of the top ten leading causes of death worldwide and its treatment poses a number of challenges. Cytarabine is a deoxycytidine analogue commonly used in the treatment of haematological malignant ... -
The synthesis of [delta]-amides of eflornithine to improve oral bioavailability
(North-West University, 2009)The oral route of drug administration has for years remained the mainstay drug delivery route because of its ease of use and good patient compliance. Orally administered drugs need to pass through a number of barriers ...
