Browsing Electronic Theses and Dissertations (ETDs) by Subject "Biomarkers"
Now showing items 1-10 of 11
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The altered urine metabolome induced by DOTS therapy in pulmonary tuberculosis patients
(North-West University (South Africa), 2023)Metabolomics holds great promise for studying complex diseases like tuberculosis (TB), where treatment outcomes are influenced by a combination of biological, environmental, and social factors. This study aimed to gain a ... -
Assessment of platinum mine tailings storage facilities : an ecotoxicological perspective
(North-West University, 2008)South Africa is one of the most important mining countries in the world, hosting the world's largest reserves of platinum group metals (PGMs). Even though mining is clearly an important activity in South Africa, contributing ... -
Cost-based optimisation of chronic heart disease interventions
(North-West University (South Africa) , Potchefstroom Campus, 2016)Coronary heart disease (CHD) is the leading cause of death by non-communicable diseases. The severity of CHD places a large economic strain on the individual, thus the need for preventative strategies. Personalising such ... -
Development and validation of an animal model of treatment resistant depression
(North-West University (South Africa) , Potchefstroom Campus, 2017)The current investigation focused on the development and validation of an animal model of treatment resistant depression (TRD). In addition, an in-depth review of biomarkers of depression was included which aimed to identify ... -
Ecotoxicological effect of CdTe quantum dots on Eisenia andrei
(North-West University (South Africa), 2020)Nanotechnology is a modern developing discipline producing a large quantity of consumer products, likely resulting in waste materials during the upcoming decades. Engineered nanoparticles with unique physicochemical ... -
Fish health, condition and biomarkers : a mechanistic and environmental perspective on copper pollution
(North-West University, 2005)Suid-Afrika het beperkte waterhulpbronne, wat tot gevolg het dat die beskikbare water van baie hoe kwaliteit moet wees. Ongelukkig word die kwaliteit van ons hulpbronne deur antropologiese impakte bedreig. Tot baie onlangs ... -
The identification of biomarkers to assist in the hydrological characterisation of a chromium polluted mine
(2013)Chromium is used in many processing applications, which has led to the formation of chromium (VI) waste. Cr(VI) is an unstable, mobile carcinogen, which is interchangeable with Cr(III) under certain environmental conditions. ... -
A metabolomics study of selected perturbations of normal human metabolism
(North-West University, 2010)Metabolism is an integrated network of biochemical pathways involving a series of enzymecatalysed anabolic or catabolic reactions in cells. Metabolites are chemical compounds that are involved in or are products ... -
A systems engineering approach to coronary heart disease
(North-West University (South Africa) , Potchefstroom Campus, 2015)Coronary heart disease (CHD) is the largest cause of death globally. This is worrying considering the substantial investments made in the research and prevention of CHD. It may be possible that the current reductionistic ... -
The use of Clarias gariepinus and associated helminthic parasites as bio-indicators of metal pollution in a subtropical ecosystem
(North-West University (South Africa), 2020)Metals are naturally occurring elements that play an important role in the functioning of organisms. However, imbalances in metal concentrations in the environment are of great concern due to their potential detrimental ...