Browsing Electronic Theses and Dissertations (ETDs) by Subject "Caffeine"
Now showing items 1-4 of 4
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The design, synthesis and evaluation of aminocaffeine derivatives as inhibitors of monoamine oxidase B
(North-West University, 2011)Monoamine oxidase (MAO) is responsible for dopamine catabolism in the brain and therefore is especially important in the treatment of Parkinson's disease (PD). MAO–B inhibition provides symptomatic relief by indirectly ... -
Identification of monoamine oxidase inhibitors using a molecular modelling approach
(2014)Monoamine oxidase (MAO) is an enzyme located on the outer mitochondrial membrane and is considered to be a target for the treatment of diseases such as Parkinson’s disease and depression. MAO may be classified into two ... -
The implementation of the delivery gap principle to develop an effective transdermal delivery system for caffeine
(2013)Caffeine is frequently used in cosmetics due to its well-characterised skin permeation properties and is widely incorporated in cosmetic-related products intended for skin (Samah & Heard, 2013:631). Despite its polar ... -
Novel sulfanyl– and sulfinylcaffeine analogues as inhibitors of monoamine oxidase
(North-West University, 2013)Parkinson’s disease (PD) is a neurodegenerative disorder, which is progressive in nature and usually associated with the elderly. It is the second most common age-related neurodegenerative disorder after Alzheimer’s disease ...