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Percutaneous absorption of cyclizine and its alkyl analogues
(North-West University, 2003)
Percutaneous delivery of drugs promises many advantages over oral or intravenous
administration, such as a better control of blood levels, a reduced incidence of systemic
toxicity, an absence of hepatic first-pass ...
Evaluation of the medication delivery process at LIFE healthcare
(North-West University, 2007)
The medication administration process in Life Healthcare is a complex, multidisciplinary process with the potential for error occurring at various stages of the
process. The complexity of the process makes it impossible ...
Percutaneous delivery of methotrexate in the absence and presence of natural permeation enhancers
(North-West University, 2003)
The transdermal delivery of drugs has a lot of advantages above other routes of delivery,
such as the avoidance of first-pass hepatic and intestinal metabolism, the non-invasive
infusion of drugs, etc. However, the ...
The transdermal absorption of 5-Fluorouracil in the presence and absence of terpenes
(North-West University, 2003)
The skin is an amazingly resilient and relatively impermeable barrier that provides protective,
perceptive and communication functions to the body (Ramachandran & Fleisher, 2000). The
stratum corneum is widely accepted ...
Skin delivery of selected hydrophilic drugs used in the treatment of skin diseases associated with HIV/AIDS by using elastic liposomes
(North-West University, 2003)
Due to the immuncompromised status of AIDS patients, secondary infections and malignancies are common. Conditions secondary to AIDS for which patients require treatment include Karposi's sarcoma (treated with methotrexate), ...
Transdermal penetration of acyclovir in the presence and absence of terpenes
(North-West University, 2003)
Acyclovir is an antiviral drug used in the treatment and prevention of herpes simplex and varicella-zoster viral infections. The major problem in the transdermal delivery of acyclovir is the permeation in sufficient amounts ...
A retrospective analysis of the usage patterns of antiretroviral drugs : a pharmacoeconomic approach
(North-West University, 2008)
More people living with HIV/AIDS reside in South Africa than any other country in the world, and the nation faces colossal challenges in broadening its response to the now-mature and widespread HIV epidemic (WHO, 2005:1). ...
Pheroid technology for the topical delivery of insulin growth factor 1 (IGF-1), keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF)
(North-West University, 2009)
The biotechnological era is here and many peptides and proteins are being used as part of
drug therapy. They are, however, not very stable and do not have the physicochemical
properties that allow for oral or topical ...
Synthesis and transdermal permeation of lamivudine derivatives
(North-West University, 2009)
The skin is the organ of the body that comes in contact with the outer environment. This means
that it has certain functions like protecting the body from excessive water loss and inhibiting the
entry of potentially ...
A comparative study between two lamellar gel phase systems and Emzaloids as delivery vehicles for the transdermal delivery of 5-fluorouracil and idoxuridine
(North-West University, 2004)
The distinctive architecture of the stratum corneum with its unique nature of an
interstitial lipoidal environment plays the major role in regulating the barrier function of the skin. The major problem with the transdermal ...