Browsing Health Sciences by Subject "Amorphous"
Now showing items 1-7 of 7
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Amorphism and polymorphism of azithromycin
(North-West University, 2012)Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ... -
The effect of solid-state forms on the topical delivery of roxithromycin
(2015)The skin is a very accessible and convenient route of administration for topical and systemic drugs (Williams, 2003:1). The only problem most formulators face is overcoming the barrier function of the stratum corneum, which ... -
Investigation of the stabilising effects of niosomes on the amorphous forms of roxithromycin
(North-West University (South Africa), Potchefstroom Campus, 2018)The first aim of this research study was to determine the effect of the excipients used in the typical niosome preparation on the solid-state nature of three solid-state forms of roxithromycin. The second aim was to ascertain ... -
The physico-chemical properties and recrystallisation kinetics of selected amorphous active ingredients
(North-West University (South Africa) , Potchefstroom Campus, 2015)During the last two to three decades the application of amorphous solid-state forms within the pharmaceutical industry gained much interest. The rationale for this heightened interest is the increased aqueous solubility, ... -
The physico–chemical properties of spiramycin and clarithromycin
(2012)In most cases, organic materials exist in the solid phase as polymorphs, solvatomorphs or amorphous forms. Physico-chemical properties in the solid-state are all affected primarily in terms of dissolution, solubility, ... -
Roxithromycin : a solubility and stability study
(North-West University, 2011)Roxithromycin is a semi-synthetic, macrolide antibiotic, derived from erythromycin A. It acts as a bacteriostatic drug at low concentrations and a bactericidal drug at high concentrations. It binds to the 50S subunit of ... -
Stability of amorphous azithromycin in a tablet formulation
(2014)It is a well-known fact that drugs can exist in different solid-state forms. These solid-state forms can be either crystalline or amorphous. Furthermore, significant differences are identified between the different solid-state ...