Browsing Health Sciences by Subject "Obsessive-compulsive disorder"
Now showing items 1-10 of 10
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Cognitive flexibility in the deer mouse and its response to escitalopram and levetiracetam
(North-West University (South-Africa), 2022)Obsessive-compulsive disorder (OCD)1 causes functional impairment which severely and negatively impacts the lives of affected individuals. As its name suggests, OCD is characterised by both obsessions and compulsions. The ... -
Cognitive flexibility in the deer mouse model of obsessive-compulsive disorder and its response to serotonin and adenosine modulation
(North-West University (South-Africa), 2021)Obsessive-compulsive disorder (OCD)1 is a phenotypically heterogeneous psychiatric disorder characterised by repetitive and ritualised behaviours (compulsions), that are purportedly enacted to attenuate the level of distress ... -
Dopaminergic and serotonergic modulation of reward appraisal in the zebrafish (Danio rerio)
(North-West University (South-Africa), 2020)Obsessive-compulsive disorder (OCD)1 is a chronic and debilitating neuropsychiatric condition affecting 1 – 3% of the world population. The condition is characterized by two main symptom cohorts namely recurrent, distressing ... -
Ethological foundations of measuring obsessive-compulsive phenotypes in the deer mouse: a methodological perspective
(North-West University (South-Africa), 2020)Pre-clinical models which leverage the study of animal behavior are invaluable tools to advance our understanding of a variety of psychological constructs. Such ethological investigations allow us to gain insight into ... -
An investigation into the potential neurobiological constructs and long-term biobehavioural effects of perinatal combined antiretroviral therapy (cART)-exposure in the deer mouse
(North-West University (South-Africa), 2022)South Africa has one of the largest combination antiretroviral treatment (cART1) programs in the world with an estimated 7.52 million individuals that were living with human immunodeficiency virus (HIV2) by the end of 2018. ... -
A metagenomic microbiome investigation in the deer mouse : a translational approach to obsessive-compulsive disorder
(North-West University (South-Africa), 2019)Obsessive-compulsive disorder (OCD)1 is characterized by persistent, intrusive and often anxiety-provoking thoughts, i.e. obsessions and/or ritualistic behaviors (compulsions) that are expressed in an attempt to reduce the ... -
Nest building and marble burying: Dopaminergic phenotyping of the deer mouse model of obsessive-compulsive disorder (OCD)
(North-West University (South-Africa), 2020)Obsessive-compulsive disorder (OCD1) is a chronic, debilitating psychiatric condition that affects 3% of the global population and is characterized by obsessions, and compulsions. 40 – 60% of patients remain treatment-resistant ... -
A pharmacological and behavioural investigation of anxiety in the deer mouse model of obsessive- compulsive disorder
(North-West University (South-Africa), 2021)Obsessive-compulsive disorder (OCD)1 is a chronic, debilitating psychiatric disorder with a global lifetime prevalence rate of 2.0%-2.9% and which generally manifests in early adulthood. The condition is characterised by ... -
A pharmacological investigation of behavioural flexibility in zebrafish (Danio rerio)
(North-West University (South-Africa), 2022)Human and animal behaviour is ultimately directed at acquiring certain outcomes or achieving certain goals, or alternatively avoiding or mitigating negative outcomes. An intricate interplay between two components of ... -
Tryptophan metabolism in the deer mouse and its response to serotonergic intervention
(North-West University (South-Africa), 2022)Obsessive-compulsive disorder (OCD)1 is a debilitating neuropsychiatric condition that notably infringes on an individual’s quality of life. The condition is characterised by two primary symptoms, namely obsessions (intrusive ...