Browsing Health Sciences by Subject "Oxidative stress"
Now showing items 1-9 of 9
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Anticancer activities of oxidant-redox drug combinations in lipid excipients
(North-West University, 2018)Genetic alterations in the redox status of cancer cells promotes a continuous and elevated production of reactive oxygen species (ROS), associated in the initiation and progression of tumours. The body's potent antioxidant ... -
Comparative study of N-acetyl cysteine and an experimental xanthone compound on behavioral, immune-inflammatory and redox biomarkers of depression in the Flinders sensitive line rat
(North-West University (South-Africa). Potchefstroom Campus, 2016)The focus of determining the underlying pathophysiological pathways of major depressive disorder (MDD) has shifted from identifying one single hypothesis to the incorporation of various aspects of the disease. Increasing ... -
Exercise-induced lipid mediator inflammatory signalling in male recreational runners versus untrained males considering potential modulating factors
(North-West University (South-Africa), 2019)Background: Resistance exercise can cause inflammation and it is known that inflammation is closely related to oxidative stress. Oxidative stress can be defined as an imbalance between free radicals and anti-oxidative ... -
An exploration into the bio-behavioural characteristics of the Ndufs4 (knockout) mice : a novel preclinical perspective on psychiatric conditions
(North-West University (South-Africa), 2023)The brain and its associated disorders as a field of study are extremely complex, even more so when research strives to create models that mimic human psychiatric conditions. Given that psychiatric illnesses are associated ... -
Haemostatic markers and cardiovascular function in black and white South Africans : the SABPA study
(2015)Motivation - In the black population of South Africa, cardiovascular disease (CVD) is rapidly increasing due to urbanisation. Stroke is usually accompanied by a pro-thrombotic haemostatic profile. Changing lifestyle factors ... -
An investigation into the potential neurobiological constructs and long-term biobehavioural effects of perinatal combined antiretroviral therapy (cART)-exposure in the deer mouse
(North-West University (South-Africa), 2022)South Africa has one of the largest combination antiretroviral treatment (cART1) programs in the world with an estimated 7.52 million individuals that were living with human immunodeficiency virus (HIV2) by the end of 2018. ... -
The role of endothelin-1 in cardiometabolic and vascular function in a bi-ethnic population : the SABPA study
(North-West University (South Africa) , Potchefstroom Campus, 2017)Motivation The black population in South Africa has a high prevalence of hypertension and atherosclerosis. Endothelin-1 (ET-1), a potent vasoconstrictor peptide, has been implicated as an important biomarker in the ... -
Studies on N-acetyl cysteine as a therapeutic intervention in methamphetamine-associated bio-behavioural changes in an immune-inflammatory model
(2015)Purpose: Schizophrenia is a severe illness, affecting 0.5-1% of the world population. The clinical manifestation of schizophrenia is characterized by three distinct categories of symptoms, namely positive, negative and ... -
Vascular function, oxidative stress and inflammation in South Africans with an active-and inactive lifestyle: the SABPA study
(North-West University (South-Africa), 2019)Motivation - Cardiovascular disease was responsible for 17.5 million deaths in 2014, which made it the main cause of mortality among non-communicable diseases. Statistics from low- and middleincome countries demonstrated ...