Browsing Health Sciences by Subject "Caco-2"
Now showing items 1-6 of 6
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Drug absorption enhancement capacities and mechanisms of action of Aloe vera gel materials
(North-West University (South Africa), Potchefstroom Campus, 2018)Oral drug delivery is one of the most preferred and user friendly routes of drug administration. Macromolecular drugs (such as peptides and proteins) generally have a poor bioavailability when administered orally. Absorption ... -
Impact of selected herbal products on intestinal epithelial permeation and metabolism of indinavir
(2014)Patients on anti-retroviral (ARV) drug treatment are sometimes simultaneously taking other prescribed drugs and/or over-the-counter drugs and/or herbal remedies. Pharmacokinetic drug-drug or herb-drug interactions can occur ... -
Investigating the absorptive and secretory transport of selected anti-malarial drugs
(North-West University, 2018)Malaria is one of the predominant infectious diseases affecting more than 200 million people a year worldwide. Artemisinin combination therapy (ACT) is currently the frontline treatment against the Plasmodium falciparum ... -
Investigation of the pharmacokinetic interactions between Hypoxis hemerocallidea and indinavir
(North-West University (South Africa) , Potchefstroom Campus, 2016)It has been established that phytochemicals in herbal medicines can result in pharmacokinetic interactions when co-administrated with allopathic drugs. These herb-drug pharmacokinetic interactions may lead to an increase ... -
Pharmacokinetic interactions of Aloe vera gel polysaccharides with indinavir
(North-West University (South Africa) , Potchefstroom Campus, 2015)Aloe vera (L.) Burm.f. (Aloe barbadensis Miller) gel and whole leaf materials have shown the ability to modulate the bioavailability of vitamins and to change the transport of molecules across intestinal epithelia. In this ... -
Rifampicin raw materials complexities and approaches to address solubility and in vitro permeability
(North-West University (South-Africa), 2021)Tuberculosis is classified as a global emergency because it is taking lives at an alarming rate and developing countries with insufficient health care systems are primarily affected. Fixed dose combination drugs (FDCs) ...