Browsing Health Sciences by Subject "Dissolution"
Now showing items 1-10 of 14
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Amorphism and polymorphism of azithromycin
(North-West University, 2012)Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ... -
The development of efavirenz and praziquantel amorphous solid dispersions
(North-West University (South-Africa), 2019)Many active pharmaceutical ingredients (API) that are highly permeable, have low aqueous solubility. Such APIs are classified as Biopharmaceutics classification system (BCS) class II drugs. Efavirenz and praziquantel both ... -
The development of paracetamol and dapsone amorphous solid dispersions
(North-West University (South-Africa), 2021)The development of APIs was focused on the crystalline form over the years, but as the poor solubility of new drugs increased, the focus turned to developing the amorphous form of the drug. Dapsone (DAP) is no exception, ... -
The development of ritonavir and pyrimethamine amorphous solid dispersions
(North-West University (South-Africa), 2021)Poorly soluble drugs are a major problem in the pharmaceutical industry. Not only does it lead to formulation difficulties, but it also leads to poor absorption and poor bioavailability of drugs. Ritonavir (RTV) is a ... -
The development of sulfadoxine and nevirapine pharmaceutical amorphous solid dispersions
(North-West University (South-Africa), 2019)Solid oral dosage forms are the most convenient and prevalent dosage form in the pharmaceutical industry although an estimated 90% of drugs currently in development can be classified as poorly soluble. These drugs will ... -
The discriminatory ability of analytical quality control test methods : a comparison of test results from different international monographs of quinine sulfate tablets
(2013)Malaria is a parasitic disease claiming one million lives worldwide annually. Unfortunately, malaria-endemic countries in need of good quality medicines are also overwhelmed with counterfeit or substandard medicine. This ... -
The effect of filler, active ingredient and Kollidon® VA64 sollubility on the release profile of the active ingredient from wet granulation tablet formulations
(North-West University, 2012)There are mainly two manufacturing processes used in the pharmaceutical industry, namely direct compression and granulation of which granulation can be subdivided into wet granulation and dry granulation. Wet granulation ... -
Evaluation and comparison of the physical properties and drug release characteristics of directly compressible lactose–based filler/binders
(North-West University, 2010)Direct compression has gained significant interest since its advent in the late 1950's due to its potential ease compared to wet granulation. The primary prerequisites for powders used in direct compression are (i) good ... -
Formulation of a chitosan multi-unit dosage form for drug delivery to the colon
(North-West University, 2006)In some diseases it is preferable that the drugs used in their treatment are released in the colon. The colon is also suitable for systemic delivery of a variety of drugs. A variety of systems have been developed for the ... -
Improvement of the pharmaceutical availability and membrane permeability of furosemide by formulation design
(North-West University (South-Africa), 2021)Furosemide is a well-known loop diuretic having weak acidic chemical properties. Furosemide belongs to the Biopharmaceutical Classification System (BCS) class IV because it has poor aqueous solubility and poor membrane ...