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Fluorescent polycyclic ligands : strategies towards the synthesis and evaluation of fluorescently labelled receptor and enzyme ligands
(North-West University, 2012)
Neurodegenerative disorders, including Alzheimer's and Parkinson's disease, and the
development of neuroprotective agents have received significant research attention in recent years. Development of novel imaging techniques ...
The synthesis and evaluation of 8–benzyloxycaffeine analogues as inhibitors of monoamine oxidase B
(North-West University, 2009)
Monoamine oxidase, especially monoamine oxidase 8 (MAO-B), plays a major role in the therapy of Parkinson's disease (PO). MAO-8 is the main enzyme responsible for the catabolism of dopamine in the substantia nigra of the ...
The influence of S-nitrosylation on the channel activity of polycyclic amines
(North-West University, 2008)
A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for possible neuroprotective activity. The premise for this study was the- recent development of a series of ...
The synthesis and evaluation of (E)-styrylisatin analogues as inhibitors of monoamine oxidase B
(North-West University, 2008)
Monoamine oxidase B (MAO-B) inhibitors are currently clinically used in the symptomatic
treatment of Parkinson's disease (PO) and may also possess .neuroprotective activity. The
irreversible MAO-'B inhibitor, (R)-deprenyl, ...
Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration
(North-West University, 2012)
Compromised calcium homeostasis in the central nervous system (CNS) is implicated as a major contributor in the pathology of neurodegeneration. Dysregulation of Ca2+ homeostasis initiates downstream Ca2+–dependent events ...
Neuroprotective effects of amantadine–flavonoid conjugates
(North-West University, 2011)
Neurodegenerative disorders like Parkinson’s and Alzheimer’s disease affect millions of people around the world. Oxidative stress has been implicated in the pathogenesis of a number of neurodegenerative disorders, cancer ...
Selective enzyme inhibition in the prevention of neuronal apoptosis : a molecular modelling study
(North-West University, 2009)
Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD) are neurodegenerative diseases which may be caused by neuronal apoptosis and there are currently no treatments to delay the progression of ...
Design and synthesis of heterocyclic compounds for neuroprotective enzyme interactions
(North-West University, 2010)
Neurodegenerative diseases are thought to be multifactorial in nature and therefore
current research focus has shifted from a ‘one-drug-one-target’ approach to that of multitarget directed ligands (MTDLs). These ligands ...
Inhibition of monoamine oxidase B by substituted coumarin derivatives
(North-West University, 2008)
Interest in the selective inhibition of monoamine oxidase B (MAO-B) has increased in the last years due to their therapeutic potential in age related neurodegenerative diseases such as Alzheimer's disease and Parkinson's ...
Antioxidant properties of Plumbago auriculata Lam
(North-West University, 2009)
Parkinson's disease, a disease first described by James Parkinson two centuries ago is one of the most common neurodegenerative diseases. The prominent feature of this disease is the selective degeneration of dopaminergic ...