HIV/AIDS poses an enormous healthcare challenge worldwide and it has become one of the leading causes of death in children. Globally, the number of people living with HIV has risen from around 8 million in 1990 to more ...

Dapsone (DDS) is currently used in the treatment of leprosy and prophylaxis of opportunistic bacterial infections in immune-compromised patients. Despite the age of this drug; not much is known about the interrelationships ...

Neurodegenerative diseases include common and debilitating disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) and post-stroke neurodegeneration. Among these disorders, PD and ...

Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ...

Methods of recrystallisation from solution using various solvents as well as physical vapour deposition (PVD) methods were employed in an attempt to create different polymorphic forms of the anti-tuberculosis drug ...

Malaria remains one on the world's most common infectious diseases with 300 to 500 million cases every year. The current treatment of malaria is restricted due to ever increasing drug resistance, cost of treatment and the ...

Human immunodeficiency virus (HIV) is a retrovirus that can lead to acquired immunodeficiency syndrome (AIDS), a condition in humans in which the immune system begins to fall, leading to life-threatening opportunistic ...

The aqueous solubility of an active pharmaceutical ingredient (API) is an important property that requires evaluation during early development and prior to formulation of the final product. With general, experimental, ...

In most cases, organic materials exist in the solid phase as polymorphs, solvatomorphs or amorphous forms. Physico-chemical properties in the solid-state are all affected primarily in terms of dissolution, solubility, ...