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The synthesis and evaluation of 8–benzyloxycaffeine analogues as inhibitors of monoamine oxidase B
(North-West University, 2009)
Monoamine oxidase, especially monoamine oxidase 8 (MAO-B), plays a major role in the therapy of Parkinson's disease (PO). MAO-8 is the main enzyme responsible for the catabolism of dopamine in the substantia nigra of the ...
The influence of S-nitrosylation on the channel activity of polycyclic amines
(North-West University, 2008)
A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for possible neuroprotective activity. The premise for this study was the- recent development of a series of ...
The synthesis and evaluation of (E)-styrylisatin analogues as inhibitors of monoamine oxidase B
(North-West University, 2008)
Monoamine oxidase B (MAO-B) inhibitors are currently clinically used in the symptomatic
treatment of Parkinson's disease (PO) and may also possess .neuroprotective activity. The
irreversible MAO-'B inhibitor, (R)-deprenyl, ...
Selective enzyme inhibition in the prevention of neuronal apoptosis : a molecular modelling study
(North-West University, 2009)
Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD) are neurodegenerative diseases which may be caused by neuronal apoptosis and there are currently no treatments to delay the progression of ...
Inhibition of monoamine oxidase B by substituted coumarin derivatives
(North-West University, 2008)
Interest in the selective inhibition of monoamine oxidase B (MAO-B) has increased in the last years due to their therapeutic potential in age related neurodegenerative diseases such as Alzheimer's disease and Parkinson's ...
Antioxidant properties of Plumbago auriculata Lam
(North-West University, 2009)
Parkinson's disease, a disease first described by James Parkinson two centuries ago is one of the most common neurodegenerative diseases. The prominent feature of this disease is the selective degeneration of dopaminergic ...
N-methyl-D-aspartate (NMDA) and sigma receptor antagonism as neuroprotective strategy for polycyclic amines
(North-West University, 2008)
Polycyclic cage compounds and their effects on different receptors and receptor channels have been studied extensively. It is evident that these compounds may prove to be of great value in future treatment of neurodegenerative ...
The antioxidant properties of 4–quinolones compared to structurally related flavonoids
(North-West University, 2009)
Oxidative stress is a common occurrence in neuro-degenerative disorders such as
Alzheimer's and Parkinson's disease and is suggested to take place before the onset of
neuro-degenerative disease, leading to, or exacerbating ...
Rational approaches towards the design of (E)-8-(3-Chlorostyryl)-caffeine derivatives as novel reversible inhibitors of monoamine oxidase B
(North-West University, 2005)
Reversible and selective inhibitors of monoamine oxidase B (MAO-B) are under
investigation for the treatment and prevention of Parkinson's disease (PD) and
Alzheimer's disease. The mechanism-based inactivator of MAO-B, ...
Polycyclic cage compounds as carrier molecules for neuroprotective non-steroidal anti-inflammatory drugs
(North-West University, 2007)
The blood brain barrier is formed by the brain capillary endothelium and plays the predominant role in controlling the passage of substances between the blood and the brain. For a compound with low blood-brain barrier ...