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Synthesis and antimalarial activity screening of artemisinin-acridine hybrids
(2013)
Malaria endemic areas not only pose a public health threat, but affects 3.3 billion people
worldwide. In 2011, estimated malaria related deaths amounted to 660 000 out of 219 million reported cases, with 81% of these and ...
Synthesis and in vitro antimalarial activity of novel chalcone derivatives
(2014)
Malaria is endemic in 106 countries worldwide. This disease is caused by a parasite from the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most virulent, with over three billion ...
Development and evaluation of a solid oral dosage form for an artesunate and mefloquine drug combination
(2014)
Malaria affects about forty percent of the world’s population. Annually more than 1.5 million fatalities due to malaria occur and parasite resistance to existing antimalarial drugs such as mefloquine has already reached ...
Formulation, characterisation and in vivo efficacy of dapsone and proguanil in trimethylated chitosan microparticles
(2014)
Malaria is an infectious disease caused by various forms of the Plasmodium parasite. It is responsible for thousands of deaths yearly with 90 % of those deaths being in sub-Saharan Africa, thus making it a disease of global ...
Preparation, stability and in vitro evaluation of liposomes containing chloroquine
(North-West University, 2010)
Malaria is currently a huge treat worldwide, as far as infections are concerned, and is
responsible for thousands of deaths per annum. The dilemma associated with the development of anti–malarial drug resistance over the ...
Preparation, stability and in vitro evaluation of liposomes containing amodiaquine
(North-West University, 2010)
Malaria is a curable disease that claims nearly one million lives each year. Problems with the treatment of malaria arise as resistance spreads and new treatment options are becoming less effective. The need for new ...
International pharmacopoeia monographs : antimalarial dosage forms
(North-West University, 2010)
Malaria is a disease affecting millions of people in 109 malarious countries and
territories, causing approximately one million deaths annually. In 2004 one of the
parasites causing human malaria, Plasmodium falciparum, ...
Efficacy enhancement of the antimalarial drugs, mefloquine and artesunate, with PheroidTM technology
(North-West University, 2010)
Malaria is currently one of the most imperative parasitic diseases in developing countries. Artesunate has a short half-life, low aqueous solubility and resultant poor and erratic absorption upon oral administration, which ...
Synthesis and biological evaluation of novel 11-azaartemisinin derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2017)
Malaria is a devastating mosquito-borne disease caused by several species of Plasmodium protozoa, of which the most important is Plasmodium falciparum (Pf). Globally, the disease caused approximately 438 000 deaths in 2014; ...
The preparation of artemisinin-cholesterol conjugates as potential new drugs for treatment of intractable forms of tuberculosis and malaria
(North-West University (South Africa) , Potchefstroom Campus, 2016)
Malaria and tuberculosis (TB) are two lethal infectious diseases that continue to plague mankind and claim many lives. These diseases are more prevalent in developing countries especially in Africa and Asia. Malaria alone ...