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The use of essential oils in relieving symptoms specific to brain malignancies : a systematic review
(North-West University (South Africa), Potchefstroom Campus, 2018)
Background
Brain-malignancy incidence is on the rise globally. Traditional treatment options for brain-malignancies such as surgery, radiation or chemotherapy bring about side-effects that may add to the already distressing ...
Effects of early-life administration of methamphetamine on the depressive-like behaviour later in life in stress-sensitive and control rats
(2013)
Methamphetamine (MA) is a well-known, easily accessible and powerful psychostimulant, and its abuse has become a global problem. MA abuse affects millions of people worldwide and places an enormous burden on public healthcare ...
The effect of early–life exposure of rats to venlafaxine on behaviour and neurological markers of antidepressant action in adulthood
(2014)
Major depression is a serious mood disorder affecting more than 120 million people worldwide, irrespective of their race or socio-economic status. This psychiatric disorder is predicted to become the second leading cause ...
The long-term effects of fluoxetine on stress-related behaviour and acute monoaminergic stress response in stress sensitive rats
(2014)
Fluoxetine and escitalopram are the only antidepressants approved by the Food and Drug Administration of the United States of America (FDA) for treatment of major depression in children and adolescents. Both drugs are ...
Endogenous markers of nitric oxide in the Flinders sensitive line (FSL) rat : a genetic animal model of depression
(North-West University, 2010)
The rising number of the population that present with major depressive disorder has intensified the need to identify and elucidate new biological markers for the diagnosis and treatment of depression. Depression presents ...
The long-term effects of methamphetamine on depressive-like behaviour and neuroplasticity in stress-sensitive rats
(2014)
Methamphetamine (METH) abuse has become a fast growing drug problem that has developed into a global epidemic. In fact, METH is one of the most commonly abused substances with an estimated 35 million abusers worldwide and ...
Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)
Purpose:
Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ...
Development and validation of an animal model of treatment resistant depression
(North-West University (South Africa) , Potchefstroom Campus, 2017)
The current investigation focused on the development and validation of an animal model of treatment resistant depression (TRD). In addition, an in-depth review of biomarkers of depression was included which aimed to identify ...
Synthesis and biological properties of synthetic methylene blue analogues
(North-West University (South Africa) , Potchefstroom Campus, 2016)
Methylene blue (MB) has diverse medical applications. Among these, MB may act as an
antimalarial agent and has demonstrated potential for the treatment of neurodegenerative
disorders such as Alzheimer’s disease. MB also ...
Behavioral, neuroendocrine and neurochemical studies on agomelatine in social isolation reared rats
(North-West University (South Africa) , Potchefstroom Campus, 2015)
1. Introduction. There is currently a large body of evidence suggesting that stressful early life experiences, such as
maternal separation and social isolation, may play a role in the development of major depressive
disorder ...