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Dihydroartemisinin esters as prodrugs against resistant P. falciparum strains
(North-West University, 2011)
Malaria is caused by the Plasmodium sp. parasite that infects the red blood cells. Of the four types of malaria, the most serious type is transmitted by Plasmodium falciparum species. It can be life threatening. The other ...
In vitro antimalarial efficacy enhancement of selected antibiotics with PheroidTM technology
(North-West University, 2010)
The Plasmodium falciparum parasite, carried by Anopheles mosquitoes, is currently a global problem due to the rising incidence of resistance of the parasite to available antimalaria drugs. Resistance and difficult treatment ...
Synthesis and antimalarial activity screening of artemisinin-acridine hybrids
(2013)
Malaria endemic areas not only pose a public health threat, but affects 3.3 billion people
worldwide. In 2011, estimated malaria related deaths amounted to 660 000 out of 219 million reported cases, with 81% of these and ...
Synthesis and in vitro antimalarial activity of novel chalcone derivatives
(2014)
Malaria is endemic in 106 countries worldwide. This disease is caused by a parasite from the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most virulent, with over three billion ...
Preparation, stability and in vitro evaluation of liposomes containing amodiaquine
(North-West University, 2010)
Malaria is a curable disease that claims nearly one million lives each year. Problems with the treatment of malaria arise as resistance spreads and new treatment options are becoming less effective. The need for new ...
Exploration of benzofuran as scaffold for the design of potent and selective PfGSK-3 inhibitors
(North-West University (South-Africa), 2021)
Control and prevention of malaria in endemic regions rely heavily on vector management (insecticide-treated bed nets and indoor residual spraying) and the limited number of effective antimalarial drugs. Unfortunately, the ...
Synthesis and in vitro antimalarial activity of esters with truncated artemisinin scaffold
(North-West University (South Africa) , Potchefstroom Campus, 2017)
Malaria is an infectious disease caused by Plasmodium parasites, with P. falciparum, responsible for most cases of morbidity and mortality. In 2014, malaria killed 438 000 people, with most deaths occurring in sub-Saharan ...
Synthesis and biological evaluation of novel 11-azaartemisinin derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2017)
Malaria is a devastating mosquito-borne disease caused by several species of Plasmodium protozoa, of which the most important is Plasmodium falciparum (Pf). Globally, the disease caused approximately 438 000 deaths in 2014; ...