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Synthesis and antimalarial activity screening of artemisinin-acridine hybrids
(2013)
Malaria endemic areas not only pose a public health threat, but affects 3.3 billion people
worldwide. In 2011, estimated malaria related deaths amounted to 660 000 out of 219 million reported cases, with 81% of these and ...
Synthesis and in vitro antimalarial activity of novel chalcone derivatives
(2014)
Malaria is endemic in 106 countries worldwide. This disease is caused by a parasite from the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most virulent, with over three billion ...
Synthesis and biological evaluation of novel artemisone derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Despite intensive international efforts to eradicate malaria, the disease, continues to inflict an enormous toll on human lives, especially in Africa. An estimated 198 million malaria cases and 584, 000 deaths were reported ...
Dihydroartemisinin esters as prodrugs against resistant P. falciparum strains
(North-West University, 2011)
Malaria is caused by the Plasmodium sp. parasite that infects the red blood cells. Of the four types of malaria, the most serious type is transmitted by Plasmodium falciparum species. It can be life threatening. The other ...