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Now showing items 11-20 of 31
Novel artemisinin derivatives with PheroidTM technology for malaria treatment
(North-West University, 2009)
Artemisinins are known for their low aqueous solubility and resultant poor and erratic absorption upon oral administration. The poor solubility and erratic absorption usually translate, to low bibavailability. Enzymatic ...
Malaria prevalence, management trends and the knock down resistance profile of Anopheles gambiae in Mbakong, Cameroon
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Malaria remains a scourge in the world. Recent efforts to combat malaria combine chemotherapy and vector control. Cameroon in 2004 adopted WHO 2001 recommendations and changed her malaria treatment guidelines from monotherapy ...
The discriminatory ability of analytical quality control test methods : a comparison of test results from different international monographs of quinine sulfate tablets
(2013)
Malaria is a parasitic disease claiming one million lives worldwide annually. Unfortunately, malaria-endemic countries in need of good quality medicines are also overwhelmed with counterfeit or substandard medicine. This ...
Synthesis, cytotoxicity and antiplasmodial activity of novel ferrocenyl-artemisinin hybrids
(North-West University (South-Africa). Potchefstroom Campus, 2019)
Malaria is caused by a parasite of the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most dangerous. This disease caused 435 thousand deaths in 2017. It is estimated that 266 thousand ...
Synthesis and in vitro antimalarial activity of esters with truncated artemisinin scaffold
(North-West University (South Africa) , Potchefstroom Campus, 2017)
Malaria is an infectious disease caused by Plasmodium parasites, with P. falciparum, responsible for most cases of morbidity and mortality. In 2014, malaria killed 438 000 people, with most deaths occurring in sub-Saharan ...
The effect of Pheroid® technology on the bioavailability of artemisone in primates
(2014)
Malaria is one the world’s most devastating diseases. Several classes of drugs are used to treat malaria. Artemisinin combination therapy is the first line treatment of uncomplicated malaria. The artemisinin derivative, ...
Artemisinin–quinoline hybrids : design, synthesis and antimalarial activity
(North-West University, 2013)
Introduction - Malaria is a major global health problem, with more than 500 million reported cases and at least 1 million deaths each year. The main problem with malaria control is the emerging drug resistance. Plasmodium ...
Radio-labelling as a tool to investigate the absorption and bio-distribution of selected antimalarial drugs
(2014)
Previous studies have shown that the formulation of an active pharmaceutical ingredient (API) entrapped in the Pheroid® (Pheroid for simplification) delivery system enhances absorption of the API, suppresses its metabolism, ...
Development of lipid matrix tablets containing a double fixed dose combination of artemisone and lumefantrine
(North-West University, 2018)
Malaria is one of the most important parasitic diseases as well as one of the most life-threatening diseases known to man. This vector-borne disease caused by Plasmodium spp., is responsible for over 438 000 deaths globally, ...
The effect of Pheroid™ technology on the bioavailability of quinoline–based anti–malarial compounds in primates
(North-West University, 2012)
Resistance against anti-malarial drugs remains one of the greatest obstacles to the effective control of malaria. The current first-line treatment regimen for uncomplicated P.falciparum malaria is based on artemisinin ...