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Now showing items 21-30 of 56
Formulation and topical delivery of lidocaine and prilocaine with the use of Pheroid™ technology
(North-West University, 2012)
Local anaesthetics are used regularly in the medical world for a variety of different procedures. Topical anaesthetics are used largely in minor skin breaking procedures, laceration repair and minor surgical procedures ...
Pheroid technology for the topical delivery of depigmenting agents transforming growth factor–ß1 and tumor necrosis factor–a
(North-West University, 2010)
Pigmentation disorders occur in multiple conditions (Hakozaki et al., 2006:105). Although many modalities of treatments are available, none are completely satisfactory (Briganti et al., 2003:101). Two cytokines normally ...
The synthesis and transdermal delivery of stavudine derivatives
(North-West University, 2006)
The skin is an amazingly flexible and relatively impermeable barrier that provides
protective, perceptive and communication functions to the human body. The interest in
transdermal drug delivery may be attributed to the ...
Transdermal delivery of 5-Fluorouracil with PheroidTM technology
(North-West University, 2008)
5-Fluorouracil (5FU) is a pyrimidine analogue, indicated for the therapy of proliferative skin diseases such as actinic keratosis (AK), superficial basal cell carcinoma and psoriasis. It has also been used for the treatment ...
PheroidTM technology for the topical application of selected cosmeceutical actives
(North-West University, 2008)
Aging can be described as an extremely complex occurrence from which no organism can be excluded. Intrinsic and extrinsic aging make out the two components of skin aging and they differ on the macromolecular level while ...
Percutaneous delivery of thalidomide and its N-alkyl analogues for treatment of rheumatoid arthritis
(Potchefstroom University for Christian Higher Education, 1998)
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease associated with high levels of tumour necrosis factor-alpha (TNF-a) in synovial fluid and synovial tissue (Saxne et al., 1989). Thalidomide is a proven ...
Topical delivery of clofazimine, artemisone and decoquinate utilizing vesicles as carrier system
(North-West University (South Africa), Potchefstroom Campus, 2018)
Artemisone, clofazimine and decoquinate are part of the MALTBRedox MRC South African University Flagship Projects, which focus on oxidant-redox drug combinations for the treatment of tuberculosis and a few other diseases. ...
Formulation of 5–Fluorouracil for transdermal delivery
(North-West University, 2010)
Non–melanoma skin cancer (NMSC) is the most common human malignancy and it is estimated that over 1.3 million cases are diagnosed each year in the United States (Neville et al., 2007:462). There are three main types of ...
Formulation, in vitro release and transdermal diffusion of diclofenac salts by implementation of the delivery gap principle
(2013)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of inflammation and pain (Escribano et al., 2003:203). Diclofenac, a classical NSAID, is considerably more effective as an analgesic, antipyretic ...
Formulation and topical delivery of liposomes and proliposomes containing clofazimine
(North-West University (South Africa) , Potchefstroom Campus, 2016)
The continual market increase in the transdermal and topical delivery of drugs makes cutaneous drug delivery exploration all the more attractive for scientists (Larraῆeta et al., 2016:62). The key in the delivery of drugs ...