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Now showing items 21-30 of 31
Development of lipid matrix tablets containing a double-fixed dose combination of artemether and lumefantrine
(North-West University (South-Africa), 2019)
Malaria remains one of the most serious vector-borne and prominent life-threatening diseases in sub-Saharan Africa. Africa has the heaviest malarial disease burden in the world, accounting for 91% of the estimated 445 000 ...
Development and evaluation of a self-emulsifying drug delivery system for artemether and lumefantrine
(North-West University (South-Africa), 2019)
Malaria is a grave concern globally, however, in sub-Saharan Africa it remains an even more severe problem due to the fact that more than 90% of all malaria cases caused by Plasmodium falciparum reside in this region. The ...
Enhancing the solubility and in vitro permeability of pyrimethamine
(North-West University (South-Africa), 2021)
ABSTRACT
Malaria poses a substantial health problem, with nearly half of the world’s population susceptible to it. Malaria causes an estimated one million deaths per year. People who fall prey to malaria are also burdened ...
Exploration of benzofuran as scaffold for the design of potent and selective PfGSK-3 inhibitors
(North-West University (South-Africa), 2021)
Control and prevention of malaria in endemic regions rely heavily on vector management (insecticide-treated bed nets and indoor residual spraying) and the limited number of effective antimalarial drugs. Unfortunately, the ...
Development and evaluation of an oral fixed–dose triple combination dosage form for artesunate, dapsone and proguanil
(North-West University, 2011)
Malaria is a life–threatening disease caused by Plasmodium spp and causes over one million deaths annually. The complex life cycle of the malaria parasite offers several points of attack for the antimalarial drugs. The ...
Evaluation and validation of methods to determine parasitemia in malaria cell cultures
(North-West University, 2008)
The success in the treatment of malaria is dependent on the prompt and accurate diagnosis of malaria and effectiveness of the drug regime used. The emerging of resistance to most antimalarial drug makes the treatment of ...
Synthesis and biological evaluation of novel artemisone derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Despite intensive international efforts to eradicate malaria, the disease, continues to inflict an enormous toll on human lives, especially in Africa. An estimated 198 million malaria cases and 584, 000 deaths were reported ...
Triazole-linked 1,4-naphthoquinone derivatives : synthesis and antiplasmodial activity
(North-West University (South-Africa). Potchefstroom Campus, 2019)
Malaria is a protozoan disease transmitted to humans through female Anopheles mosquitoes.
The malaria parasite thrives in tropical areas, thus people there are at higher risk, especially in
third-world countries like ...
Preclinical evaluation of the possible enhancement of the efficacy of anti-malarial drugs by pheroid technology
(North-West University, 2007)
Malaria is currently one of the most imperative parasitic diseases of the developing world. Current effective treatment options are limited because of increasing drug resistance, treatment cost effectiveness and treatment ...
In vitro antimalarial efficacy enhancement of selected antibiotics with PheroidTM technology
(North-West University, 2010)
The Plasmodium falciparum parasite, carried by Anopheles mosquitoes, is currently a global problem due to the rising incidence of resistance of the parasite to available antimalaria drugs. Resistance and difficult treatment ...