Acne vulgaris is the single, most common disease that presents a significant challenge to dermatologists, due to its complexity, prevalence and range of clinical expressions. This condition can be found in 85% of teenage ...

Skin ageing is an unavoidable biological phenomenon inextricably linked to menopause. The rapid and drastic decline in oestrogen levels brought about by menopause has a profound effect on skin integrity and physiology, ...

Statins are used for the medical treatment of hypercholesterolemia, but after oral administration, it may cause gastro-intestinal disturbances and first-pass hepatic metabolism may decrease the bioavailability. Hence, the ...

In order to achieve successful receptor binding affinity at complex pharmacological targets the majority of drugs are of a lipophilic nature. However, optimisation of drug delivery systems for lipophilic drugs presents ...

Hypercholesterolemia can be described as high levels of low-density lipoproteins (LDL) that accumulate in the cells of the body including the liver, spleen and the intestines. Cholesterol is eliminated by increasing ...

The skin provides an essential protective barrier between the internal tissues and the environment. A wound is defined as a defect or a break in the skin barrier as a result of physical or thermal damage. Wounds may also ...

The aim of this in vitro study was to investigate the efficacy of the novel Pheroid™ technology system in a semi-solid dosage form, for the topical delivery of acyclovir (5% w/w), an anti-viral agent and ketoconazole (2% ...

The aim of this study was to investigate in vitro transdermal delivery of the antiviral drug, acyclovir and the antifungal drug, ketoconazole, with the aid of the novel Pheroid™ drug delivery system. Since its appearance ...

Emulsions are widely used as the delivery vehicles of active ingredients. The aim of this project was the investigation of the effect of the emulsifier system on dermal and transdermal delivery. Four different actives with ...

The aim of this study was to investigate in vitro transdermal diffusion of a small peptide namely arginine vasopressin (AVP) with the aid of the novel PheroidTM drug delivery system. Generally, peptides seem unfit for ...