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Now showing items 31-34 of 34
In silico screening, synthesis and in vitro determination of the biological activities of D-amino acid oxidase inhibitors
(North-West University (South-Africa), 2022)
Schizophrenia is a mental disorder with many clinical and therapeutic challenges. Current therapy is based on outdated pathological theories while most antipschycotic drugs have a significant side effect profile. New ...
Structure-activity relationship of methylene blue and its analogues as lead compounds for novel antidepressant development
(North-West University, 2010)
Antidepressants target serotonergic and/or catecholaminergic responses in an attempt at treating depression yet are at best 65% effective. New antidepressants, as well as new targets for antidepressant action, are thus ...
The preparation and evaluation of xanthinyl analogues as inhibitors of monoamine oxidase B
(North-West University, 2006)
Monoamine oxidase B (MAO-B) is a drug target for the treatment of neurodegenerative diseases such as Parkinson's disease. For example, the mechanism-based inactivator of MAO-B,
(R)-deprenyl, is frequently used in combination ...
In vitro and in silico antimicrobial evaluation of N- methyl-2-phenylmaleimides
(North-West University (South-Africa), 2023)
Due to COVID-19, many other pandemics have been overlooked in the past few years.
Antimicrobial resistance (AMR) is a pandemic that have killed more people than Human
Immunodeficiency Virus (HIV) and malaria in 2019 and ...