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Synthesis and transdermal penetration of cytarabine and selected amide, ester and carbamate derivatives
(North-West University, 2009)
Cancer is reported to be one of the top ten leading causes of death worldwide and its treatment poses a number of challenges. Cytarabine is a deoxycytidine analogue commonly used in the treatment of haematological malignant ...
Synthesis and transdermal permeation of lamivudine derivatives
(North-West University, 2009)
The skin is the organ of the body that comes in contact with the outer environment. This means
that it has certain functions like protecting the body from excessive water loss and inhibiting the
entry of potentially ...
The synthesis and transdermal delivery of stavudine derivatives
(North-West University, 2006)
The skin is an amazingly flexible and relatively impermeable barrier that provides
protective, perceptive and communication functions to the human body. The interest in
transdermal drug delivery may be attributed to the ...
Percutaneous absorption of cyclizine and its alkyl analogues
(North-West University, 2003)
Percutaneous delivery of drugs promises many advantages over oral or intravenous
administration, such as a better control of blood levels, a reduced incidence of systemic
toxicity, an absence of hepatic first-pass ...