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A comparative study between two lamellar gel phase systems and Emzaloids as delivery vehicles for the transdermal delivery of 5-fluorouracil and idoxuridine
(North-West University, 2004)
The distinctive architecture of the stratum corneum with its unique nature of an
interstitial lipoidal environment plays the major role in regulating the barrier function of the skin. The major problem with the transdermal ...
A study to correlate drug absorption in humans (Fa) to in vitro intestinal permeation using the Sweetana-Grass diffusion model
(North-West University, 2006)
Background: The oral route still remains the most popular method for drug delivery as it is convenient, cost efficient and has high patient compliance. However, for a drug to be successfully administered via this route it ...
Synthesis and transdermal penetration of cytarabine and selected amide, ester and carbamate derivatives
(North-West University, 2009)
Cancer is reported to be one of the top ten leading causes of death worldwide and its treatment poses a number of challenges. Cytarabine is a deoxycytidine analogue commonly used in the treatment of haematological malignant ...
Synthesis and transdermal permeation of lamivudine derivatives
(North-West University, 2009)
The skin is the organ of the body that comes in contact with the outer environment. This means
that it has certain functions like protecting the body from excessive water loss and inhibiting the
entry of potentially ...
Formulation, in vitro release and transdermal diffusion of salicylic acid and topical niacinamide
(North-West University, 2009)
Acne affects as many as 80% of young adults and adolescents all over the world. This detrimental condition can be classified into four stages: (a) open comedo (blackhead), (b) closed comedo (whitehead), (c) papule and (d) ...
Formulation, in vitro release and transdermal diffusion of vitamin B3 for treatment of acne
(North-West University, 2009)
Acne is an extremely common condition, affecting almost 80% of adolescents and young adults. It is an inflammatory disease, characterised by comedones, papules, pustules and sometimes cysts. Factors causing acne include ...
Formulation, in-vitro release and transdermal diffusion of alpha-lipoic acid
(North-West University, 2009)
Acne is a common disease characterised by follicular hyperkeratinisation, bacterial hipercolonisation as well as immune reactions and inflammation. In acne, reactive oxygen species (ROS) may be released from the damaged ...
The synthesis and transdermal delivery of stavudine derivatives
(North-West University, 2006)
The skin is an amazingly flexible and relatively impermeable barrier that provides
protective, perceptive and communication functions to the human body. The interest in
transdermal drug delivery may be attributed to the ...
Transdermal delivery of 5-Fluorouracil with PheroidTM technology
(North-West University, 2008)
5-Fluorouracil (5FU) is a pyrimidine analogue, indicated for the therapy of proliferative skin diseases such as actinic keratosis (AK), superficial basal cell carcinoma and psoriasis. It has also been used for the treatment ...
PheroidTM technology for the topical application of selected cosmeceutical actives
(North-West University, 2008)
Aging can be described as an extremely complex occurrence from which no organism can be excluded. Intrinsic and extrinsic aging make out the two components of skin aging and they differ on the macromolecular level while ...