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Influence of particle size on solubility of active pharmaceutical ingredients
(North-West University, 2012)
The aqueous solubility of an active pharmaceutical ingredient (API) is an important property that requires evaluation during early development and prior to formulation of the final product. With general, experimental, ...
Thermal kinetics and crystal structure of dapsone polymorphs and solvates
(North-West University, 2012)
Dapsone (DDS) is currently used in the treatment of leprosy and prophylaxis of opportunistic bacterial infections in immune-compromised patients. Despite the age of this drug; not much is known about the interrelationships ...
The development of efavirenz and praziquantel amorphous solid dispersions
(North-West University (South-Africa), 2019)
Many active pharmaceutical ingredients (API) that are highly permeable, have low aqueous solubility. Such APIs are classified as Biopharmaceutics classification system (BCS) class II drugs. Efavirenz and praziquantel both ...
The development of sulfadoxine and nevirapine pharmaceutical amorphous solid dispersions
(North-West University (South-Africa), 2019)
Solid oral dosage forms are the most convenient and prevalent dosage form in the pharmaceutical industry although an estimated 90% of drugs currently in development can be classified as poorly soluble. These drugs will ...
Artesunate - An investigation into polymorphism
(North-West University (South-Africa), 2020)
Artesunate (ART) is a derivative of artemisinin and is used in the treatment of uncomplicated Plasmodium falciparum (P. falciparum) malaria. Limited and unreliable solid-state and physico-chemical data is currently available ...
Rifampicin raw materials complexities and approaches to address solubility and in vitro permeability
(North-West University (South-Africa), 2021)
Tuberculosis is classified as a global emergency because it is taking lives at an alarming rate and developing countries with insufficient health care systems are primarily affected. Fixed dose combination drugs (FDCs) ...
The development of paracetamol and dapsone amorphous solid dispersions
(North-West University (South-Africa), 2021)
The development of APIs was focused on the crystalline form over the years, but as the poor
solubility of new drugs increased, the focus turned to developing the amorphous form of the
drug. Dapsone (DAP) is no exception, ...