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Stability of amorphous azithromycin in a tablet formulation
(2014)
It is a well-known fact that drugs can exist in different solid-state forms. These solid-state forms can be either crystalline or amorphous. Furthermore, significant differences are identified between the different solid-state ...
The physico-chemical properties and recrystallisation kinetics of selected amorphous active ingredients
(North-West University (South Africa) , Potchefstroom Campus, 2015)
During the last two to three decades the application of amorphous solid-state forms within the pharmaceutical industry gained much interest. The rationale for this heightened interest is the increased aqueous solubility, ...
Amorphism and polymorphism of azithromycin
(North-West University, 2012)
Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ...
Roxithromycin : a solubility and stability study
(North-West University, 2011)
Roxithromycin is a semi-synthetic, macrolide antibiotic, derived from erythromycin A. It acts as a bacteriostatic drug at low concentrations and a bactericidal drug at high concentrations. It binds to the 50S subunit of ...
The development of efavirenz and praziquantel amorphous solid dispersions
(North-West University (South-Africa), 2019)
Many active pharmaceutical ingredients (API) that are highly permeable, have low aqueous solubility. Such APIs are classified as Biopharmaceutics classification system (BCS) class II drugs. Efavirenz and praziquantel both ...
Development of a stability indicating HPLC method for the Pheroid™ delivery system
(North-West University, 2010)
Stability plays an important role in the development of a new drug product. High Performance Liquid Chromatography (HPLC) is considered a stability indicating method of analysis. It is widely used in the pharmaceutical ...
The development of paracetamol and dapsone amorphous solid dispersions
(North-West University (South-Africa), 2021)
The development of APIs was focused on the crystalline form over the years, but as the poor
solubility of new drugs increased, the focus turned to developing the amorphous form of the
drug. Dapsone (DAP) is no exception, ...