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The physico–chemical properties of spiramycin and clarithromycin
(2012)
In most cases, organic materials exist in the solid phase as polymorphs, solvatomorphs or amorphous forms. Physico-chemical properties in the solid-state are all affected primarily in terms of dissolution, solubility, ...
Quality specifications for the antimalarial compound lumefantrine and products thereof
(2011)
Malaria has been responsible for the deaths of thousands of people annually and is
considered one of the biggest health challenges globally. In order to ensure that
patients in malaria affected areas receive products of ...
Application of nanocoatings produced by electrostatic layer-by-layer self-assembling to improve the physicochemical properties of drugs and excipients
(2014)
Layer-by-layer (LbL) is a self-assembly technique, proven to be a simplified method for the modification of material surfaces. The LbL multilayers are formed due to electrostatic attraction between opposite charged polymers. ...
Stability of amorphous azithromycin in a tablet formulation
(2014)
It is a well-known fact that drugs can exist in different solid-state forms. These solid-state forms can be either crystalline or amorphous. Furthermore, significant differences are identified between the different solid-state ...
The impact of PheroidTM technology on the bioavailability and efficacy of anti-tuberculosis drugs in an animal model
(North-West University, 2009)
Tuberculosis (TB) is a worldwide pandemic with vast challenges in the fight against the
disease. Challenges include the long and tedious treatment regimens and chemotherapy with
adverse side effects. One approach in ...
The physico-chemical properties and recrystallisation kinetics of selected amorphous active ingredients
(North-West University (South Africa) , Potchefstroom Campus, 2015)
During the last two to three decades the application of amorphous solid-state forms within the pharmaceutical industry gained much interest. The rationale for this heightened interest is the increased aqueous solubility, ...
Polymorphism and pseudopolymorphism of clarithromycin
(North-West University, 2005)
Clarithromycin is a 14-membered-ring , macrolide antibiotic, a derivative of
erythromycin, that is commonly used for the treatment of chronic, obstructive upper - and lower respiratory -, skin - and soft tissue -, as well ...
PheroidTM-based anti-malarial formulations : HPLC method development and stability studies
(North-West University, 2008)
Malaria remains one on the world's most common infectious diseases with 300 to 500 million cases every year. The current treatment of malaria is restricted due to ever increasing drug resistance, cost of treatment and the ...
Influence of particle size on solubility of active pharmaceutical ingredients
(North-West University, 2012)
The aqueous solubility of an active pharmaceutical ingredient (API) is an important property that requires evaluation during early development and prior to formulation of the final product. With general, experimental, ...
Thermal kinetics and crystal structure of dapsone polymorphs and solvates
(North-West University, 2012)
Dapsone (DDS) is currently used in the treatment of leprosy and prophylaxis of opportunistic bacterial infections in immune-compromised patients. Despite the age of this drug; not much is known about the interrelationships ...