Browsing Natural and Agricultural Sciences by Author "10066136 - Erasmus, Elardus (Supervisor)"
Now showing items 1-13 of 13
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An analytical method to investigate the estrogen metabolism in women taking combined oral contraceptives
Jacobs, C.L. (North-West University, 2018)The human body is exposed to numerous (endogenous and exogenous) toxins daily. The body has a protective mechanism to help detoxify certain toxins, through biotransformation processes. However, when exposure exceeds the ... -
An analytical method to investigate the metabolites and co-factors of the methionine-homocysteine cycle in women using combined oral contraceptives and non-users
Jacobs, Tarien (North-West University (South Africa), 2022)Biotransformation protects the body from endogenous and exogenous substances like combined oral contraceptives (COCs). During biotransformation, estrogen undergoes methylation with the assistance of catechol-O-methyltransferase ... -
Carnitine conjugation profiling in a selected cohort of patients with chronic fatigue syndrome
Du Plessis, L. (North-West University, 2019)Chronic fatigue syndrome (CFS) is classified by the World Health Organisation (WHO) as a non-communicable disease. Fatigue is a symptom commonly experienced by many individuals and is also a symptom associated with a wide ... -
Characterization of the enzyme activity and substrate specificity of GLYAT haplotypes
Schutte, Chantelle (North-West University (South Africa), 2020)The unavoidable exposure to xenobiotics makes detoxification a necessity. Detoxification is not just one reaction but four reactions (Phase 0, I, II and III) that work together. The glycine conjugation pathway is one of ... -
Effect of oral contraception on biotransformation, oxidative stress and oxidative damage
Swiegers, Marlie (North-West University (South Africa), Potchefstroom Campus, 2015)The first hormonal oral contraceptive was released in 1960, giving women a more efficient way of controlling pregnancy and family planning. A combined oral contraceptive (COC) consists of an estrogen and a progestin compound. ... -
The effect of sulforaphane on oxidative stress and biotransformation in HepaRG cells
Crous, Ané (North-West University, 2013)Sulforaphane is an isothiocyanate found in high concentrations in cruciferous vegetables like broccoli. Sulforaphane has received much attention due to the evidence that it inhibits phase I carcinogen-bioactivating enzymes ... -
Expression of recombinant human metallothionein 2A as internal standard for mass spectrometric analysis of metallothioneins
Lindeque, Jeremie Zander (North-West University, 2007)The induction of metallothionein (MT) expression in mitochondrial disorders has been well studied on the transcription level by means of RNA measurements in an attempt to understand and confirm the function of this protein ... -
Glycine conjugate detoxification profiling with sodium benzoate loading tests in a selected population of the North-West University
Venter, Tania (North-West University, 2007)The glycine conjugation system is an essential detoxification system needed to detoxify a variety of xenobiotics, including sodium benzoate, a very commonly used preservative. Recently more than 100 single nucleotide ... -
The influence of 17-β-estradiol on bioenergetic and estrogen metabolism in macrophages
Tollemache, Abigail (North-West University (South Africa), 2023)Breast cancer is a multifactorial disease influenced by a variety of factors in the tumour microenvironment (TME), including hormones such as estrogen, and immune cells such as macrophages. Imbalances in estrogen metabolism ... -
Investigation of the bi-substrate kinetics of a recombinant human glycine N-acyltransferase with a known non-synonymous single nucleotide polymorphism (N156S)
Ungerer, Vida (North-West University (South Africa), Potchefstroom Campus, 2015)Biotransformation is fast becoming a buzzword of our time. This is due to the ever increasing exposure of humans to xenobiotic substances. The detoxification of these xenobiotics occur via various detoxifying mechanisms ... -
Die ontwikkeling van 'n tandem-massaspektrometriese metode as bevestigende analise vir koolhidraat metaboliese defekte
Dercksen, Marli (North-West University, 2006)The study of carbohydrate structure and -metabolism has indicated the importance of these compounds in the human body. Metabolic defects in the carbohydrate metabolism, for example galactosemia and glycogen storage ... -
Quantification of selected energy and redox markers in blood samples of chronic fatigue syndrome patients
Moolman, Chantalle (2014)Chronic, noncommunicable diseases such as chronic fatigue syndrome (also known as myalgic encephalomyelitis) are rapidly becoming a worldwide epidemic that profoundly affects public health and productivity. Chronic fatigue ... -
Urinary 1,4–dihydroxynonene mercapturic acid (DHN–MA) and 8–hydroxy–2'–deoxyguanosine (8–OHdG) as markers of oxidative damage : the SABPA study
Steenkamp, Leandrie (North-West University, 2010)The human body has evolved certain defence mechanisms to cope with the high occurrence of free radicals. These radicals are obtained endogenously from the mitochondria, peroxisomes, the cytochrome P450 (CYP 450) system and ...