Browsing Natural and Agricultural Sciences by Subject "Oxidative stress"
Now showing items 1-10 of 13
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Agrochemicals related to maize crops in South Africa and associated biological effects : an in vitro study
(North-West University (South Africa), 2023)Although agrochemicals reduce pest-associated crop losses, these chemicals end up in non-target environments following rainfall and irrigation. When fractions of agrochemical mixtures are bioavailable, they pose a threat ... -
The effect of different ozone concentrations on white blood cell energy homeostasis
(North-West University, 2006)Ozone therapy is an alternative form of therapy that has gained attention in the last couple of years. It is believed that O3 may exert a stimulatory effect on the antioxidant defence and immune systems and may therefore ... -
The effect of metallothionein overexpression on the transcription of selected genes involved in one-carbon metabolism and oxidative stress in NDUFS4-deficient mouse tissues
(North-West University (South Africa), 2020)Respiratory complex I (CI) defects are the most common mitochondrial disease, for which treatment is limited. Additionally, there is a lack of understanding of the impact of a CI defect upon the gene expression regulation ... -
Effect of oral contraception on biotransformation, oxidative stress and oxidative damage
(North-West University (South Africa), Potchefstroom Campus, 2015)The first hormonal oral contraceptive was released in 1960, giving women a more efficient way of controlling pregnancy and family planning. A combined oral contraceptive (COC) consists of an estrogen and a progestin compound. ... -
The effect of sulforaphane on oxidative stress and biotransformation in HepaRG cells
(North-West University, 2013)Sulforaphane is an isothiocyanate found in high concentrations in cruciferous vegetables like broccoli. Sulforaphane has received much attention due to the evidence that it inhibits phase I carcinogen-bioactivating enzymes ... -
The effects of radiolabelled agents used in the diagnosis and treatment of cancer, on inflammatory cytokines
(North-West University (South Africa), 2020)This study was conducted to determine the effects that two radiolabelled compounds have on the inflammatory cytokines and oxidative stress biomarkers in xenograft Rowett nude (RNU) rat models. Safety and efficacy are of ... -
The influence of neonatal intake of curcumin on lipid metabolism : implication on obesity model
(North-West University (South Africa), 2022)The high prevalence of obesity and related metabolic disorders due to increased consumption of fructose-rich diet is a serious global threat to the public’s health among children and adolescents. Obesity is associated with ... -
Investigation into the protection of mitochondrial disease pathology by metallothionein overexpression
(North-West University (South Africa), 2020)Mitochondrial diseases (MD), such as Leigh Syndrome (LS), present with severe neurological and muscular phenotypes in patients, but have no known cure and limited treatment options. Based on their neuroprotective effects ... -
Investigation of the involvement of mitochondrial DNA variants in cardiometabolic disease : the SABPA study
(North-West University (South Africa), Potchefstroom Campus, 2017)Mitochondria are intricately involved in cell homeostatic and adaptive stress signalling pathways, and play a central role in cell differentiation, proliferation and death. Consequently, mitochondrial dysfunction has been ... -
The involvement of lipid and protein oxidation in hypertension : the SABPA study
(North-West University, 2012)Oxidative stress, caused by increased levels of reactive oxygen species (ROS)and reactive nitrogen species (RNS) and/or a decrease in antioxidant capacity, can result in the oxidation of various bio-molecules, such as ...