Browsing Natural and Agricultural Sciences by Subject "Glycine conjugation"
Now showing items 1-5 of 5
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AKSM2A en AKSM2B ensiemtoets optimalisering en rekombinante uitdrukking
(North-West University (South Africa). Potchefstroom Campus, 2019)Glisienkonjugasie is ʼn Fase 2-biotransformasieweg wat verantwoordelik is vir die detoksifisering van xenobiotika soos bensoaat en salisilaat. Hierdie biotransformasieweg is gekonserveerd en speel ʼn baie belangrike rol in ... -
The establishment of a model system in which variants of the medium-chain ligase (ACSM) and glycine N-acyltransferase (GLYAT) can be co-expressed and analysed
(North-West University (South Africa), 2022)Even though glycine conjugation pathway discovery dates back to the 18th century, it is still an important detoxification pathway that is severely neglected in research. Xenobiotics are omnipresent in the environment (as ... -
Investigation of the bi-substrate kinetics of a recombinant human glycine N-acyltransferase with a known non-synonymous single nucleotide polymorphism (N156S)
(North-West University (South Africa), Potchefstroom Campus, 2015)Biotransformation is fast becoming a buzzword of our time. This is due to the ever increasing exposure of humans to xenobiotic substances. The detoxification of these xenobiotics occur via various detoxifying mechanisms ... -
Phase 2 biotransformation : the targeted profiling of glycine amino acid conjugation
(North-West University (South Africa), Potchefstroom Campus, 2015)The hepatic biotransformation system plays an important role in drug metabolism and toxicity and has been studied quite extensively. The importance of the very first biotransformation reaction discovered, namely phase 2 ... -
The recombinant expression and enzymatic charaterisation of human ACSM2 ligase.
(North-West University (South Africa), 2023-10)Glycine conjugation is a highly conserved Phase 2 biotransformation reaction for xenobiotic carboxylic acids such as benzoate, salicylate, and medium-chain fatty acids. The glycine conjugation pathway can be saturated by ...