Show simple item record

dc.contributor.authorIslam, M.S.
dc.contributor.authorChoi, H.
dc.contributor.authorLoots, Du Toit
dc.date.accessioned2010-02-03T07:32:23Z
dc.date.available2010-02-03T07:32:23Z
dc.date.issued2008
dc.identifier.citationIslam, M.S. et al. 2008. Effects of dietary onion (Allium cepa L.) in a rodent model of high-fat diet streptozotocin-induced diabetes. Annals of nutrition and metabolism, 53(1):6-12. [https://doi.org/10.1159/000152868]en
dc.identifier.issn0250-6807
dc.identifier.issn1421-9697 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/2805
dc.identifier.urihttps://doi.org/10.1159/000152868
dc.identifier.urihttps://www.karger.com/Article/Abstract/152868
dc.description.abstractBackground/Aims: The present study was conducted to investigate the effects of two dietary doses of freeze-dried onion powder on diabetes-related symptoms in a high-fat (HF) diet streptozotocin (STZ)-induced diabetes rat model. Methods: Five-week-old male Sprague-Dawley rats were fed a HF diet for 2 weeks and then randomly divided into 4 groups as follows: HF control (HFC), diabetic control (DBC), onion low (ONL; 0.5%) and onion high (ONH; 2.0%). Diabetes was induced by an intraperitoneal injection of STZ (40 mg/kg body weight) in all groups except the HFC group. Results: After 4 weeks on the experimental diets, fasting blood glucose levels for both onion-fed groups were higher than in the DBC and HFC groups, albeit only significantly so (p < 0.05) in the ONL group. Serum insulin concentrations and insulin resistance were dose-dependently increased (however, not significantly so) in the onion-fed groups compared to the DBC group. Pancreatic β-cell function and liver glycogen concentrations were nonsignificantly higher in the DBC and ONH groups compared to the ONL group. Additionally, the ONH group had significantly higher lipid concentrations (except for high-density lipoprotein cholesterol) compared to all other groups. The ONL group showed a similar hyperlipidemic trend, however to a lesser extent, with only triglycerides significantly differing from those of the DBC and HFC groups. Conclusion: The results suggest that the HF onion diet may increase insulin secretion and consequently insulin resistance in a dose-dependent manner, resulting in a worsened hyperglycemic and hyperlipidemic diabetic state. We conclude that higher dietary fat may impair the antidiabetic effects of dietary onion intake as has been previously reported.
dc.language.isoenen
dc.publisherKargeren
dc.subjectType 2 diabetes
dc.subjectOnion
dc.subjectAllium cepa L.
dc.subjectHigh-fat diet
dc.subjectRats
dc.titleEffects of dieatry onion (Allium cepa L.) in a rodent model of high-fat diet streptozotocin-induced diabetesen
dc.typeArticleen
dc.contributor.researchID10799508 - Loots, Du Toit


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record