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    Ketamine and rapidly acting antidepressants: breaking the speed of sound or light?

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    Date
    2018
    Author
    Berk, Michael
    Harvey, Brian H.
    Loo, Collen
    Davey, Christopher G.
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    Abstract
    There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key uncertainty is whether there is a finite speed limit imposed by the critical role of homeostatic adaptive mechanisms that underpin the efficacy and onset of available psychotropic agents and whether this is mutable with emerging agents with potential rapid onset, in particular ketamine
    URI
    http://hdl.handle.net/10394/28786
    http://journals.sagepub.com/doi/abs/10.1177/0004867418783567
    https://doi.org/10.1177/0004867418783567
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    • Faculty of Health Sciences [2376]

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