Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement
Harvey, Brian H.
Stein, Dan J.
Harvey, Brian H.
Stein, Dan J.
MetadataShow full item record
Symptoms of posttraumatic stress disorder are often precipitated by sensory cues in the form of visual, auditory, olfactory and gustatory “flashbacks” resulting in enhanced fear-memory consolidation and the characteristic symptoms of re-experiencing, avoidance and hyper-arousal. Single prolonged stress with and without re-stress have been used to explore the neurobiology of this disorder, particularly with respect to contextual conditioning and spatial memory impairment. However, less work has been done regarding associative sensory-related memories linked to aversive events. Although growing evidence supports a role for cholinergic pathways in stress, this has not been studied in the above animal models. We studied the effects of single prolonged stress with and without re-stress on conditioned taste aversion learning in rats, together with differential analysis of frontal cortical and hippocampal [3H]-quinuclidinyl benzylate ([3H]-QNB) muscarinic receptor binding. Single prolonged stress with and without re-stress both enhanced associative sensory aversion learning 7 days after stressor-taste pairing, although re-stress did not strengthen this response. Increased cortical and hippocampal muscarinic receptor density (Bmax) was found 7 days after single prolonged stress with re-stress, although receptor affinity remained unaltered. Frontal cortical and hippocampal muscarinic receptor changes may thus underlie conditioned taste aversion learning in rats exposed to stress and re-stress. These data suggest that it may be useful to study the role of cholinergic pathways in mediating associative memory in psychiatric disorders such as posttraumatic stress disorder
- Faculty of Health Sciences 
Showing items related by title, author, creator and subject.
Die belewing van stres en die gebruik van cope-vaardighede deur departementshoofde van skole : riglyne vir ondersteuning Oberholzer, Jan Adriaan (North-West University, 2006)An investigation into stress experience and the use of coping skills by departemental heads of schools: guidelines for support. Stress occurs when one's perception of demands exceeds his perception of his abilities to meet ...
Smit, Estie (North-West University, 2011)In terms of section 186(1)(e) of the Labour Relations Act 66 of 1995 constructive dismissal occurs where an employee terminated a contract of employment with or without notice because the employer made continued employment ...
Pelser, Anna Magrieta Fredrika (2015)This study focuses on stress management of educators, and specifically in the Mahikeng Area. The study consists of four appropriately researched sections (paraphrased in article format), namely: - The first article place ...