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dc.contributor.authorMöller, Marisa
dc.contributor.authorFourie, Jaco
dc.contributor.authorHarvey, Brian H.
dc.date.accessioned2018-09-10T09:53:02Z
dc.date.available2018-09-10T09:53:02Z
dc.date.issued2018
dc.identifier.citationMöller, M. et al. 2018. Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats. Scientific reports, 8(1): Article no 12837. [https://doi.org/10.1038/s41598-018-29978-3]en_US
dc.identifier.issn2045-2322 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/30940
dc.identifier.urihttps://doi.org/10.1038/s41598-018-29978-3
dc.identifier.urihttps://www.nature.com/articles/s41598-018-29978-3.pdf
dc.description.abstractEfavirenz is abused in a cannabis-containing mixture known as Nyaope. The addictive-like effects of efavirenz (5, 10 and 20 mg/kg) was explored using conditioned place preference (CPP) in rats following sub-acute exposure vs. methamphetamine (MA; 1 mg/kg) and Δ9-tetrahydrocannabinol (THC; 0.75 mg/ kg). The most addictive dose of efavirenz was then compared to THC alone and THC plus efavirenz following sub-chronic exposure using multiple behavioural measures, viz. CPP, sucrose preference test (SPT) and locomotor activity. Peripheral superoxide dismutase (SOD), regional brain lipid peroxidation and monoamines were also determined. Sub-acute efavirenz (5 mg/kg) had a significant rewarding effect in the CPP comparable to MA and THC. Sub-chronic efavirenz (5 mg/kg) and THC + efavirenz were equally rewarding using CPP, with increased cortico-striatal dopamine (DA), and increased lipid peroxidation and SOD. Sub-chronic THC did not produce CPP but significantly increased SOD and decreased hippocampal DA. Sub-chronic THC + efavirenz was hedonic in the SPT and superior to THC alone regarding cortico-striatal lipid peroxidation and sucrose preference. THC + efavirenz increased cortico-striatal DA and decreased serotonin (5-HT). Concluding, efavirenz has dose-dependent rewarding effects, increases oxidative stress and alters regional brain monoamines. Efavirenz is hedonic when combined with THC, highlighting its abuse potential when combined with THCen_US
dc.language.isoenen_US
dc.publisherNatureen_US
dc.subjectPreclinical researchen_US
dc.subjectTranslational researchen_US
dc.titleEfavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in ratsen_US
dc.typeArticleen_US
dc.contributor.researchID21247250 - Möller Wolmarans, Marisa
dc.contributor.researchID11083417 - Harvey, Brian Herbert


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