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dc.contributor.authorMandiwana, Vusani
dc.contributor.authorGrobler, Anne
dc.contributor.authorZeevaart, Jan Rijn
dc.contributor.authorKalombo, Lonji
dc.date.accessioned2018-09-26T06:43:20Z
dc.date.available2018-09-26T06:43:20Z
dc.date.issued2018
dc.identifier.citationMandiwana, V. et al. 2018. 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles. Applied radiation and isotopes, 141:51-56. [https://doi.org/10.1016/j.apradiso.2018.08.015]en_US
dc.identifier.issn0969-8043
dc.identifier.issn1872-9800 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/31111
dc.identifier.urihttps://doi.org/10.1016/j.apradiso.2018.08.015
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0969804317307005
dc.description.abstractThe aim of this study was to establish the in vivo uptake and tissue distribution of 99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive 99mTc-MDP encapsulated into SLNs was administered to rats to trace their biodistribution through imaging and ex vivo studies. As expected IV injected 99mTc-MDP exhibited predominant visual bone uptake and a high localisation of particles in the kidneys (3.87%ID/g) followed by bone (2.66%ID/g). IV administered 99mTc-MDP encapsulated by SLN showed similar uptake than 99mTc-MDP. Orally administrated 99mTc-MDP showed no uptake in any organs except the GI-tract while orally administered 99mTc-MDP-SLN showed distinct transfer of 99mTc-MDP from the GI tract with measurable levels in the kidneys and boneen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectBiodistributionen_US
dc.subjectIn vivo imagingen_US
dc.subjectSLNsen_US
dc.subject99mTc-MDPen_US
dc.title99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticlesen_US
dc.typeArticleen_US
dc.contributor.researchID24045756 - Mandiwana, Vusani
dc.contributor.researchID11008857 - Grobler, Anne Frederica
dc.contributor.researchID16951484 - Zeevaart, Jan Rijn


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