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dc.contributor.authorStrauss, Michél
dc.contributor.authorSmith, Wayne
dc.contributor.authorSchutte, Aletta E.
dc.contributor.authorWei, Wen
dc.contributor.authorBagrov, Alexei Y.
dc.date.accessioned2018-11-13T13:18:28Z
dc.date.available2018-11-13T13:18:28Z
dc.date.issued2018
dc.identifier.citationStrauss, M. et al. 2018. Large artery stiffness is associated with marinobufagenin in young adults: the African-PREDICT study. Journal of hypertension, 36(12):2333-2339. [https://doi.org/10.1097/HJH.0000000000001866]en_US
dc.identifier.issn0263-6352
dc.identifier.issn1473-5598 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/31699
dc.identifier.urihttps://journals.lww.com/jhypertension/Fulltext/2018/12000/Large_artery_stiffness_is_associated_with.8.aspx
dc.identifier.urihttps://doi.org/10.1097/HJH.0000000000001866
dc.description.abstractObjectives: The cardiotonic steroid, marinobufagenin (MBG), has been shown to play a physiological natriuretic role in response to salt intake. However, recent studies in clinical and animal models demonstrated possible links between elevated levels of endogenous MBG and increased arterial stiffness. Large artery stiffness is a known predictor of future cardiovascular disease. We, therefore, investigated whether large artery stiffness relates to 24-h urinary MBG excretion in young apparently healthy black and white adults. Methods: This study included data of 711 participants (black 51%, men 42%, mean age 24.8 ± 3.02 years). We measured the carotid–femoral pulse wave velocity (cfPWV), 24-h urinary MBG and sodium excretion. Results: In single, partial and multivariable adjusted (Adj.) regression analyses, we found a persistent positive association between cfPWV and MBG excretion in women [Adj. R 2 = 0.23; standardized (std.) β = 0.15; P = 0.002], but not men (Adj. R 2 = 0.17; std. β = 0.06; P = 0.31). Multiple regression models were adjusted for ethnicity, age, waist-to-height ratio, mean arterial pressure, high-density lipoprotein cholesterol, C-reactive protein, γ-glutamyl transferase and glucose. Conclusion: In conclusion, already at a young age heightened endogenous MBG levels may contribute to large artery stiffness in women via pressure-independent mechanisms, increasing their risk for future cardiovascular diseaseen_US
dc.language.isoenen_US
dc.publisherWolters Kluweren_US
dc.subjectHealthyen_US
dc.subjectMarinobufageninen_US
dc.subjectPulse wave velocityen_US
dc.subjectSalten_US
dc.subjectSodiumen_US
dc.subjectYoung adulten_US
dc.titleLarge artery stiffness is associated with marinobufagenin in young adults: the African-PREDICT studyen_US
dc.typeArticleen_US
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID22945717 - Smith, Wayne
dc.contributor.researchID23423714 - Strauss, Michél


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