Show simple item record

dc.contributor.authorGreffrath, Wilhelm P.
dc.contributor.authorDu Plessis, Jesslee M.
dc.contributor.authorViljoen, Michelle
dc.contributor.authorCockeran, Marike
dc.date.accessioned2018-11-15T11:16:00Z
dc.date.available2018-11-15T11:16:00Z
dc.date.issued2018
dc.identifier.citationGreffrath, W.P. et al. 2018. Hypertriglyceridaemia and the risk of pancreatitis six months post lopinavir/ritonavir initiation. Southern African journal of HIV medicine, 19(1): Article no 766. [https://doi.org/10.4102/sajhivmed.v19i1.766]en_US
dc.identifier.issn1608-9693
dc.identifier.issn2078-6751 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/31714
dc.identifier.urihttps://doi.org/10.4102/sajhivmed.v19i1.766
dc.identifier.urihttps://sajhivmed.org.za/index.php/hivmed/article/view/766/1185
dc.description.abstractBackground: Hypertriglyceridaemia (HTG) is an important risk factor for pancreatitis and cardiovascular disease (CVD), depending on severity. Hypertriglyceridaemia is common in human immunodeficiency virus (HIV) infection and is also a common complication of lopinavir/ritonavir (LPV/r). Objectives: To evaluate the risk of pancreatitis associated with HTG in patients six months post initiation of LPV/r-based therapy in a regional public hospital. Methods: Triglyceride (TG), serum amylase (s-amylase) and CD4+ count values were retrospectively investigated six months post LPV/r-based initiation. Age, gender, previous antiretroviral regimen and period since HIV diagnosis were also recorded. Results: The final sample consisted of 194 patients, 50 males and 144 females; mean (± standard deviation [s.d.]) age was 39.52 (± 9.98) years, and the mean (± s.d.) period since HIV diagnosis was 91.32 (± 25.18) months. Normal TG levels (< 1.70 mmol/L) were detected in only 55% of patients and the rest presented with some degree of HTG. The mean (± s.d.) TG for the entire sample was elevated at 1.94 (± 1.30) mmol/L with the mean (± s.d.) of the males at 2.36 (± 1.74) – statistically higher compared to the females at 1.79 (± 1.08) mmol/L (p = 0.034). No cases of pancreatitis were recorded and the time since HIV diagnosis did not indicate any statistically significant differences in the means of the TG, serum amylase or CD4 count values. Conclusion: Triglyceride levels were not substantially elevated to induce pancreatitis at six months post initiation of LPV/r, but were elevated above the accepted upper normal limit of 1.70 mmol/L which may have implications for cardiovascular risken_US
dc.language.isoenen_US
dc.publisherAOSISen_US
dc.subjectHypertriglyceridaemiaen_US
dc.subjectPancreatitisen_US
dc.subjectLopinavir/ritonaviren_US
dc.subjectCardiovascular risken_US
dc.titleHypertriglyceridaemia and the risk of pancreatitis six months post lopinavir/ritonavir initiationen_US
dc.typeArticleen_US
dc.contributor.researchID20984634 - Du Plessis, Jesslee Melinda
dc.contributor.researchID10215344 - Viljoen, Michelle
dc.contributor.researchID21102007 - Cockeran, Marike


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record