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dc.contributor.authorJansen van Vuren, Esmé
dc.contributor.authorMalan, Leoné
dc.contributor.authorVon Känel, Roland
dc.contributor.authorLammertyn, Liandi
dc.contributor.authorCockeran, Marike
dc.contributor.authorMalan, Nicolaas T.
dc.identifier.citationJansen van Vuren, E. et al. 2019. Longitudinal changes of cardiac troponin and inflammation reflect progressive myocyte stretch and likelihood for hypertension in a Black male cohort: the SABPA study. Hypertension research, 42:708-716. []en_US
dc.identifier.issn1348-4214 (Online)
dc.description.abstractInflammation was cross-sectionally associated with subclinical wall remodeling and hypertension. Whether longitudinal changes (∆) in inflammation, myocyte injury (troponin T), and stretch (N-terminal-pro-B-type natriuretic peptide) are associated with hypertension and ECG left ventricular hypertrophy (ECG-LVH) is unclear. The first prospective analysis in Africa assessing these associations included a cohort of Black and White teachers (N = 338; aged 20–63 years). Fasting blood samples were obtained to measure tumor necrosis factor-alpha (TNF-α), cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Ambulatory blood pressure, 2-lead ECG and resting 10-lead ECG values were obtained. A higher mean hypertensive status (62%) was evident in Blacks compared to Whites (44%, p < 0.001). Over 3-years, NT-proBNP increased in both ethnic groups. No associations were evident in women or in White men. In Black men, ECG-LVH at follow-up was positively associated with baseline cTnT (Adj R2 0.43; β = 0.48; 95% CI 0.28–0.68, p < 0.001) and baseline SBP (Adj R2 0.43; β = 0.29; 95% CI 0.09–0.49, p = 0.006). In Black men, baseline TNF-α (OR = 1.49, 95% CI 1.05–2.14, p = 0.03) and decreased ΔTNF-α (OR = 2.07, 95% CI 1.26–3.40, p = 0.004) increased the likelihood for cTnT levels ≥ 4.2 ng/L. Here, baseline NT-proBNP (OR = 1.12, 95% CI 1.01–1.23, p = 0.03) and ΔNT-proBNP progression (OR = 1.09, 95% CI 1.00–1.81, p = 0.04) increased the likelihood for 24-h hypertension. In conclusion, chronically increased levels of markers of myocyte injury accompanied by progressive myocardial stretch, reflective of cardiac metabolic overdemand, may ultimately increase hypertension and ischemic heart disease risk in a cohort of Black malesen_US
dc.subjectCardiac troponin T
dc.subjectTumor necrosis factor-α
dc.subjectBlack men
dc.titleLongitudinal changes of cardiac troponin and inflammation reflect progressive myocyte stretch and likelihood for hypertension in a Black male cohort: the SABPA studyen_US
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID25499777 - Von Känel, Roland
dc.contributor.researchID21102007 - Cockeran, Marike
dc.contributor.researchID20088310 - Lammertyn, Leandi
dc.contributor.researchID22820388 - Jansen van Vuren, Esmé

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