Relationship between serum omega-3 fatty acid and asthma endpoints
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Date
2019Author
Adams, Shahieda
Smuts, Cornelius M.
Lopata, Andreas L.
Baatjies, Roslynn
Jeebhay, Mohamed F.
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Show full item recordAbstract
Recent studies have highlighted the potential protective role of omega-3 polyunsaturated fatty
acids (n-3 PUFA) in asthma. This study aimed at determining the association between seafood intake,
serum PUFA composition and clinical endpoints of asthma in adults. A cross-sectional study of
642 subjects used the European Committee Respiratory Health Survey (ECRHS) questionnaire,
skin prick tests, spirometry and methacholine challenge tests following ATS guidelines. Sera was
analysed for n-3 and n-6 PUFA composition. Subjects had a mean age of 34 years, were largely female
(65%) and 51% were current smokers. While 99% reported fish consumption, rock lobster, mussels,
squid and abalone were also consumed less frequently. The prevalence of asthma symptoms was 11%,
current asthma (ECRHS definition) was 8% and non-specific bronchial hyperresponsiveness (NSBH)
was much higher (26%) In adjusted models the n-3 PUFAs 20:5 (EPA) and 22:5 (DPA) were significantly
associated with a decreased risk of having NSBH. Total n-3 PUFA composition was associated with
decreased NSBH risk (OR = 0.92), while high n-6 PUFA composition was associated with an increased
risk (OR = 1.14)
URI
http://hdl.handle.net/10394/31856https://www.mdpi.com/1660-4601/16/1/43/pdf
https://doi.org/10.3390/ijerph16010043
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- Faculty of Health Sciences [2379]