Urinary metabolites and their link with premature arterial stiffness in black boys: the ASOS study
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Date
2018Author
Erasmus, Dalene
Mels, Carina M.C.
Louw, Roan
Lindeque, J. Zander
Kruger, Ruan
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Background and Aims: Black boys (6–8 years of age) were shown to have higher pulse wave
velocity with potential early vascular compromise. We aimed to compare predefined urinary
metabolites in black and white boys to explore associations of pulse wave velocity with these
metabolites. Methods and Results: We included 40 white and 40 black apparently healthy
boys between the ages of 6 and 8 years. Femoral pulse wave velocity was measured along
with various metabolites using liquid chromatography tandem mass spectrometry (LC-MS/
MS) and gas chromatography-time of flight-mass spectrometry (GC-TOF-MS) methods. Pulse
wave velocity and diastolic blood pressure were higher in the black compared to the white
boys (both p ≤ 0.002). Isovalerylcarnitine was lower and 1-metylhistidine tended to be lower
(p = 0.002 and p = 0.073, respectively), whereas L-proline levels tended to be higher (p = 0.079)
in the black compared to the white boys. In single, partial, and multiple regression analyses,
pulse wave velocity correlated inversely with β-alanine (β = –0.414; p = 0.008) and 1-methylhistidine (β = –0.347; p = 0.032) and positively with L-proline (β = 0.420; p = 0.008), threonic
acid (β = 0.977; p = 0.033), and malonic acid (β = 0.348; p = 0.030) in black boys only. Conclusion: Our study is the first to discover the associations of pulse wave velocity with β-alanine,
1-methylhistidine, and L-proline in children from South Africa, which may suggest potential
early compromise in cardiac protective metabolic pathways in black boys as young as 6 years
of age
URI
http://hdl.handle.net/10394/32336https://www.karger.com/Article/Pdf/492155
https://doi.org/10.1159/000492155