• Login
    View Item 
    •   NWU-IR Home
    • Research Output
    • Faculty of Health Sciences
    • View Item
    •   NWU-IR Home
    • Research Output
    • Faculty of Health Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    BDNF increases associated with constant troponin T levels and may protect against poor cognitive interference control: the SABPA prospective study

    Thumbnail
    Date
    2019
    Author
    Jansen van Vuren, Esmé
    Malan, Leoné
    Von Känel, Roland
    Lammertyn, Leandi
    Malan, Nicolaas T.
    Metadata
    Show full item record
    Abstract
    Background: Brain‐derived neurotrophic factor (BDNF) modulates brain health and cognition, which can interfere with executive cognitive function. BDNF was impli-cated with microcirculatory ischaemia and may reflect cardiomyocyte injury. We aimed to determine whether prospective changes (%Δ) in BDNF and cardiac tro-ponin T (cTnT) will be associated with executive cognitive function in a bi‐ethnic cohort.Design: A prospective investigation was conducted over a three‐year period in a bi‐ethnic sex cohort (N = 338; aged 20‐65 years) from South Africa. Fasting serum samples for BDNF and cTnT were obtained. The STROOP‐color‐word conflict test (CWT) was applied to assess executive cognitive function at baseline.Results: In Blacks, BDNF (P< 0.001) increased over the three‐year period while cTnT did not change. In contrast, in Whites, BDNF and cTnT decreased over three years. In Black men, no change in cTnT was associated with increased ΔBDNF (β= 0.25; 95% CI 0.05‐0.45; P= 0.02). In the Black men, constant cTnT levels were inversely associated with executive cognitive function (β= −0.33; 95% CI −0.53 to −0.12; P = 0.003). Three‐year increases in BDNF increased the likelihood for chronic lower cTnT levels at a pre‐established cut‐point of <4.2 ng/L [OR = 2.35 (1.12‐4.94), P = 0.02]. The above associations were not found in the White sex groups.Conclusions: Central neural control mechanisms may have upregulated BDNF in Black men as a way to protect against myocardial stress progression and to possibly improve processes related to cognitive interference control. High‐sensitive cTnT lev-els may act as an early predictor of disturbed neural control mechanisms
    URI
    http://hdl.handle.net/10394/32491
    https://onlinelibrary.wiley.com/doi/epdf/10.1111/eci.13116
    https://doi.org/10.1111/eci.13116
    Collections
    • Faculty of Health Sciences [2404]

    Copyright © North-West University
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of NWU-IR Communities & CollectionsBy Issue DateAuthorsTitlesSubjectsAdvisor/SupervisorThesis TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsAdvisor/SupervisorThesis Type

    My Account

    LoginRegister

    Copyright © North-West University
    Contact Us | Send Feedback
    Theme by 
    Atmire NV