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dc.contributor.authorJansen van Vuren, Esmé
dc.contributor.authorMalan, Leoné
dc.contributor.authorVon Känel, Roland
dc.contributor.authorLammertyn, Leandi
dc.contributor.authorMalan, Nicolaas T.
dc.identifier.citationJansen van Vuren, E. et al. 2019. BDNF increases associated with constant troponin T levels and may protect against poor cognitive interference control: the SABPA prospective study. European journal of clinical ionvestigation, 49(7): Article no e13116. []en_US
dc.identifier.issn1365-2362 (Online)
dc.description.abstractBackground: Brain‐derived neurotrophic factor (BDNF) modulates brain health and cognition, which can interfere with executive cognitive function. BDNF was impli-cated with microcirculatory ischaemia and may reflect cardiomyocyte injury. We aimed to determine whether prospective changes (%Δ) in BDNF and cardiac tro-ponin T (cTnT) will be associated with executive cognitive function in a bi‐ethnic cohort.Design: A prospective investigation was conducted over a three‐year period in a bi‐ethnic sex cohort (N = 338; aged 20‐65 years) from South Africa. Fasting serum samples for BDNF and cTnT were obtained. The STROOP‐color‐word conflict test (CWT) was applied to assess executive cognitive function at baseline.Results: In Blacks, BDNF (P< 0.001) increased over the three‐year period while cTnT did not change. In contrast, in Whites, BDNF and cTnT decreased over three years. In Black men, no change in cTnT was associated with increased ΔBDNF (β= 0.25; 95% CI 0.05‐0.45; P= 0.02). In the Black men, constant cTnT levels were inversely associated with executive cognitive function (β= −0.33; 95% CI −0.53 to −0.12; P = 0.003). Three‐year increases in BDNF increased the likelihood for chronic lower cTnT levels at a pre‐established cut‐point of <4.2 ng/L [OR = 2.35 (1.12‐4.94), P = 0.02]. The above associations were not found in the White sex groups.Conclusions: Central neural control mechanisms may have upregulated BDNF in Black men as a way to protect against myocardial stress progression and to possibly improve processes related to cognitive interference control. High‐sensitive cTnT lev-els may act as an early predictor of disturbed neural control mechanismsen_US
dc.subjectBlack menen_US
dc.subjectMyocardial injuryen_US
dc.titleBDNF increases associated with constant troponin T levels and may protect against poor cognitive interference control: the SABPA prospective studyen_US
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID25499777 - Von Känel, Roland
dc.contributor.researchID20088310 - Lammertyn, Leandi
dc.contributor.researchID22820388 - Jansen van Vuren, Esmé

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