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dc.contributor.authorCoertze, Roelof Dirk
dc.contributor.authorBezuidenhout, Cornelius Carlos
dc.identifier.citationCoertze, R.D. & Bezuidenhout, C.C. 2019. Global distribution and current research of AmpC beta-lactamase genes in aquatic environments: a systematic review. Environmental pollution, 252:1633-1642. []en_US
dc.identifier.issn1873-6424 (Online)
dc.description.abstractAmpC beta-lactamase genes are some of the most common antibiotic resistance genes and require special attention once they have become mobilised. The detection of these genes is well documented in clinical settings. However, there is insufficient knowledge of both plasmid and genomic AmpC genes in aquatic environments. This systematic review aimed to determine the extent of the knowledge gap in the literature regarding the prevalence of AmpC beta-lactamase genes in aquatic systems. Using selected criteria, a total of 27 databases were searched for applicable peer-reviewed journal articles. No date and language restrictions were applied. Journal articles that highlighted the detection of AmpC beta-lactamase genes in environmental aquatic systems, including wastewater treatment plants, were included. Of the 950 literature sources that were identified, 50 were selected for full text analysis based on predetermined criteria. Studies on AmpC genes detection were traced in 23 countries. These studies focused on surface water (24), wastewater (17), sea water (4) and both surface and wastewater (5). Most studies did not specifically aim to detect AmpC genes, but to detect antibiotic resistance genes in general. Presently no surveillance protocols, standardised detection methods or environmental limits exist for these genes and, due to a paucity of research in this field, it is unlikely that such systems will be implemented in the near future. The implications and dynamics of AmpC genes in aquatic systems remain unclear and require intense research to ensure the sustainability of environmental systems and human healthen_US
dc.subjectAmpC beta-lactamase genesen_US
dc.subjectGlobal distributionen_US
dc.subjectAquatic systemsen_US
dc.titleGlobal distribution and current research of AmpC beta-lactamase genes in aquatic environments: a systematic reviewen_US
dc.contributor.researchID12540110 - Bezuidenhout, Cornelius Carlos
dc.contributor.researchID23535334 - Coertze, Roelof Dirk

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